Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease - Fig 3

J. Kenneth Baillie (177195)
Andrew Bretherick (4903141)
Christopher S. Haley (4903156)
Sara Clohisey (4747563)
Alan Gray (3276414)
Lucile P. A. Neyton (4903150)
Jeffrey Barrett (4903153)
Eli A. Stahl (229145)
Albert Tenesa (107674)
Robin Andersson (3501872)
J. Ben Brown (4903144)
Geoffrey J. Faulkner (481019)
Marina Lizio (185917)
Ulf Schaefer (237265)
Carsten Daub (3815110)
Masayoshi Itoh (15728)
Naoto Kondo (32868)
Timo Lassmann (14297)
Jun Kawai (13865)
Damian Mole (4903138)
Vladimir B. Bajic (8687)
Peter Heutink (39587)
Michael Rehli (18004)
Hideya Kawaji (13861)
Albin Sandelin (2089)
Harukazu Suzuki (15733)
Jack Satsangi (259264)
Christine A. Wells (200908)
Nir Hacohen (220591)
Thomas C. Freeman (4903147)
Yoshihide Hayashizaki (3101)
Piero Carninci (3015)
Alistair R. R. Forrest (185918)
David A. Hume (87441)

March 2018

<p>(a) A subset of regulatory elements is identified containing disease-associated SNPs. (b) The str...

All SNPs Are Not Created Equal: Genome-Wide Association Studies Reveal a Consistent Pattern of Enrichment among Functionally Annotated SNPs

Andrew J. Schork (407292)
Wesley K. Thompson (407291)
Phillip Pham (407350)
Ali Torkamani (237060)
J. Cooper Roddey (407293)
Patrick F. Sullivan (143608)
John R. Kelsoe (104920)
Michael C. O'Donovan (170200)
Helena Furberg (407351)
Nicholas J. Schork (176346)
Ole A. Andreassen (170286)
Anders M. Dale (127526)

April 2013

<div><p>Recent results indicate that genome-wide association studies (GWAS) have the potential to ex...

Article Allelic expression mapping across cellular lineages to establish impact of non-coding SNPs

Veronique Adoue
Alicia Schiavi
Nicholas Light
Jonas Carlsson Almlöf
Per Lundmark
Bing Ge
Tony Kwan
Maxime Caron
Lars Rönnblom
Chuan Wang
Shu-huang Chen
Alison H Goodall
Francois Cambien
Panos Deloukas
Willem H Ouweh
Ann-christine Syvänen
Tomi Pastinen

August 2016

Most complex disease-associated genetic variants are located in non-coding regions and are therefore...

Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease - Fig 5

J. Kenneth Baillie (177195)
Andrew Bretherick (4903141)
Christopher S. Haley (4903156)
Sara Clohisey (4747563)
Alan Gray (3276414)
Lucile P. A. Neyton (4903150)
Jeffrey Barrett (4903153)
Eli A. Stahl (229145)
Albert Tenesa (107674)
Robin Andersson (3501872)
J. Ben Brown (4903144)
Geoffrey J. Faulkner (481019)
Marina Lizio (185917)
Ulf Schaefer (237265)
Carsten Daub (3815110)
Masayoshi Itoh (15728)
Naoto Kondo (32868)
Timo Lassmann (14297)
Jun Kawai (13865)
Damian Mole (4903138)
Vladimir B. Bajic (8687)
Peter Heutink (39587)
Michael Rehli (18004)
Hideya Kawaji (13861)
Albin Sandelin (2089)
Harukazu Suzuki (15733)
Jack Satsangi (259264)
Christine A. Wells (200908)
Nir Hacohen (220591)
Thomas C. Freeman (4903147)
Yoshihide Hayashizaki (3101)
Piero Carninci (3015)
Alistair R. R. Forrest (185918)
David A. Hume (87441)

March 2018

<p><b>(a) Relationship between GWAS p-value for a SNP, and coexpression scores of individual promote...

Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease

J. Kenneth Baillie (177195)
Andrew Bretherick (4903141)
Christopher S. Haley (4903156)
Sara Clohisey (4747563)
Alan Gray (3276414)
Lucile P. A. Neyton (4903150)
Jeffrey Barrett (4903153)
Eli A. Stahl (229145)
Albert Tenesa (107674)
Robin Andersson (3501872)
J. Ben Brown (4903144)
Geoffrey J. Faulkner (481019)
Marina Lizio (185917)
Ulf Schaefer (237265)
Carsten Daub (3815110)
Masayoshi Itoh (15728)
Naoto Kondo (32868)
Timo Lassmann (14297)
Jun Kawai (13865)
Damian Mole (4903138)
Vladimir B. Bajic (8687)
Peter Heutink (39587)
Michael Rehli (18004)
Hideya Kawaji (13861)
Albin Sandelin (2089)
Harukazu Suzuki (15733)
Jack Satsangi (259264)
Christine A. Wells (200908)
Nir Hacohen (220591)
Thomas C. Freeman (4903147)
Yoshihide Hayashizaki (3101)
Piero Carninci (3015)
Alistair R. R. Forrest (185918)
David A. Hume (87441)

March 2018

<div><p>Genetic variants underlying complex traits, including disease susceptibility, are enriched w...

Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease.

J Kenneth Baillie
Andrew Bretherick
Christopher S Haley
Sara Clohisey
Alan Gray
Lucile P A Neyton
Jeffrey Barrett
Eli A Stahl
Albert Tenesa
Robin Andersson
J Ben Brown
Geoffrey J Faulkner
Marina Lizio
Ulf Schaefer
Carsten Daub
Masayoshi Itoh
Naoto Kondo
Timo Lassmann
Jun Kawai
Damian Mole
Vladimir B Bajic
Peter Heutink
Michael Rehli
Hideya Kawaji
Albin Sandelin
Harukazu Suzuki
Jack Satsangi
Christine A Wells
Nir Hacohen
Thomas C Freeman
Yoshihide Hayashizaki
Piero Carninci
Alistair R R Forrest
David A Hume

March 2018

Genetic variants underlying complex traits, including disease susceptibility, are enriched within th...

Assigning Co-Regulated Human Genes and Regulatory Gene Clusters

Tobias Strunz
Martin Kellner
Christina Kiel
Bernhard H. F. Weber

September 2021

Elucidating the role of genetic variation in the regulation of gene expression is key to understandi...

Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types.

Finucane, Hilary K
Reshef, Yakir A
Anttila, Verneri
Slowikowski, Kamil
Gusev, Alexander
Byrnes, Andrea
Gazal, Steven
Loh, Po-Ru
Lareau, Caleb
Shoresh, Noam
Genovese, Giulio
Saunders, Arpiar
Macosko, Evan
Pollack, Samuela
Brainstorm Consortium
Perry, John
Buenrostro, Jason D
Bernstein, Bradley E
Raychaudhuri, Soumya
McCarroll, Steven
Neale, Benjamin M
Price, Alkes L

April 2018

We introduce an approach to identify disease-relevant tissues and cell types by analyzing gene expre...

All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs

Schork, AJ
Thompson, WK
Pham, P
Torkamani, A
Roddey, JC
Sullivan, PF
Kelsoe, JR
O’Donovan, MC
Furberg, H
The Tobacco and Genetics Consortium
Schizophrenia Psychiatric Genomics Consortium
The Bipolar Disorder Psychiatric Genomics Consortium
Schork, NJ
Andreassen, OA
Dale, AM

April 2013

Recent results indicate that genome-wide association studies (GWAS) have the potential to explain mu...

Cluster analysis of differential histone modification levels at transcriptional start sites reveals groups of co-regulated genes associated with immune-relevant functions.

Sebastian Weiterer (535133)
Florian Uhle (250479)
Christoph Lichtenstern (707424)
Benedikt H. Siegler (707425)
Sabin Bhuju (107606)
Michael Jarek (166845)
Marek Bartkuhn (31889)
Markus A. Weigand (535137)

March 2015

<p>A) Heat map indicates result of un-supervised hierarchical clustering for 743 gene promoters with...

Revealing the genetic basis of inter-individual variation in the abundance of immune cell types in a complex tissue.

Yael Steuerman (2586448)
Irit Gat-Viks (48213)

April 2016

<p>(<b>A</b>) A simple reference data. Shown are three cell types (<i>c1-c3</i>, left to right); eac...

All SNPs are not created equal: Genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs

Schork, A.J.
Thompson, W.K.
Pham, P.
Torkamani, A.
Roddey, J.C.
Sullivan, P.F.
Kelsoe, J.
O'Donovan, M.C.
Furberg, H.
Absher, D.
Agudo, A.
Almgren, P.
Ardissino, D.
Assimes, T.L.
Bandinelli, S.
Barzan, L.
Bencko, V.
Benhamou, S.
Benjamin, E.J.
Bernardinelli, L.
Bis, J.
Boehnke, M.
Boerwinkle, E.
Boomsma, D.I.
Brennan, P.
Canova, C.
Castellsagué, X.
Chanock, S.
Chasman, D.I.
Conway, D.I.
Dackor, J.
de Geus, E.J.C.
Duan, J.
Elosua, R.
Everett, B.
Fabianova, E.
Ferrucci, L.
Foretova, L.
Fortmann, S.P.
Franceschini, N.
Frayling, T.M.
Furberg, C.
Gejman, P.V.
Groop, L.
Gu, F.
Guralnik, J.
Hankinson, S.E.
Haritunians, T.
Healy, C.
Hofman, A.
Holcátová, I.
Hunter, D.J.
Hwang, S.J.
Ioannidis, J.P.A.
Iribarren, C.
Jackson, A.U.
Janout, V.
Kaprio, J.
Kim, Y.
Kjaerheim, K.
Knowles, J.W.
Kraft, P.
Ladenvall, C.
Lagiou, P.
Lanthrop, M.
Lerman, C.
Levinson, D.F.
Levy, D.
Li, M.D.
Lin, D.Y.
Lips, E.H.
Lissowska, J.
Lowry, R.B.
Lucas, G.
Macfarlane, T.V.
Maes, H.H.M.
Mannucci, P.M.
Mates, D.
Mauri, F.
McGovern, J.A.
McKay, J.D.
McKnight, B.
Melander, O.
Merlini, P.A.
Milaneschi, Y.
Mohlke, K.L.
O'Donnell, C.J.
Pare, G.
Penninx, B.W.J.H.
Perry, J.R.B.
Posthuma, D.
Preis, S.R.
Psaty, B.
Quertermous, T.
Ramachandran, V.S.
Richiardi, L.
Ridker, P.M.
Rose, J.
Rudnai, P.
Salomaa, V.
Sanders, A.R.
Schwartz, S.M.
Shi, J.
Smit, J.H.
Stringham, H.M.
Szeszenia-Dabrowska, N.
Tanaka, T.
Taylor, K.
Thacker, E.E.
Thornton, L.
Tiemeier, H.
Tuomilehto, J.
Uitterlinden, A.G.
van Duijn, C.M.
Vink, J.M.
Vogelzangs, N.
Voight, B.F.
Walter, S.
Willemsen, G.
Zaridze, D.
Znaor, A.
Akil, H.
Anjorin, A.
Backlund, L.
Badner, J.A.
Barchas, J.D.
Barrett, T.
Bass, N.
Bauer, M.
Bellivier, F.
Bergen, S.E.
Berrettini, W.
Blackwood, D.
Bloss, C.S.
Breen, G.
Breuer, R.
Bunner, W.E.
Burmeister, M.
Byerley, W. F.
Caesar, S.
Chambert, K.
Cichon, S.
St Clair, D.
Collier, D.A.
Corvin, A.
Coryell, W.H.
Craddock, N.
Craig, D.W.
Daly, M.
Day, R.
Degenhardt, F.
Djurovic, S.
Dudbridge, F.
Edenberg, H.J.
Elkin, A.
Etain, B.
Farmer, A.E.
Ferreira, M.A.
Ferrier, I.
Flickinger, M.
Foroud, T.
Frank, J.
Fraser, C.
Frisén, L.
Gershon, E.S.
Gill, M.
Gordon-Smith, K.
Green, E.K.
Greenwood, T.A.
Grozeva, D.
Guan, W.
Gurling, H.
Gustafsson, O.
Hamshere, M.L.
Hautzinger, M.
Herms, S.
Hipolito, M.
Holmans, P.A.
Hultman, C. M.
Jamain, S.
Jones, E.G.
Jones, I.
Jones, L.
Kandaswamy, R.
Kennedy, J.L.
Kirov, G. K.
Koller, D.L.
Kwan, P.
Landén, M.
Langstrom, N.
Lathrop, M.
Lawrence, J.
Lawson, W.B.
Leboyer, M.
Lee, P.H.
Li, J.
Lichtenstein, P.
Lin, D.
Liu, C.
Lohoff, F.W.
Lucae, S.
Mahon, P.B.
Maier, W.
Martin, N.G.
Mattheisen, M.
Matthews, K.
Mattingsdal, M.
McGhee, K.A.
McGuffin, P.
McInnis, M.G.
McIntosh, A.
McKinney, R.
McLean, A.W.
McMahon, F.J.
McQuillin, A.
Meier, S.
Melle, I.
Meng, F.
Mitchell, P.B.
Montgomery, G.W.
Moran, J.
Morken, G.
Morris, D.W.
Moskvina, V.
Muglia, P.
Mühleisen, T.W.
Muir, W.J.
Müller-Myhsok, B.
Myers, R.M.
Nievergelt, C.M.
Nikolov, I.
Nimgaonkar, V.L.
Nöthen, M.M.
Nurnberger, J.I.
Nwulia, E.A.
O'Dushlaine, C.
Osby, U.
Óskarsson, H.
Owen, M.J.
Petursson, H.
Pickard, B.S.
Porgeirsson, P.
Potash, J.B.
Propping, P.
Purcell, S.M.
Quinn, E.
Raychaudhuri, S.
Rice, J.
Rietschel, M.
Ruderfer, D.
Schalling, M.
Schatzberg, A.F.
Scheftner, W.A.
Schofield, P.R.
Schulze, T.G.
Schumacher, J.
Schwarz, M.M.
Scolnick, E.
Scott, L.J.
Shilling, P.D.
Sigurdsson, E.
Sklar, P.
Smith, E.N.
Stefansson, H.
Stefansson, K.
Steffens, M
Steinberg, S.
Strauss, J.
Strohmaier, J.
Szelinger, S.
Thompson, R.C.
Tozzi, F.
Treutlein, J.
Vincent, J.B.
Watson, S.J.
Wienker, T.F.
Williamson, R.
Witt, S.H.
Wright, A.
Xu, W.
Young, A.H.
Zandi, P.P.
Zhang, P.
Zöllner, S.
Agartz, I.
Albus, M.
Alexander, M.
Amdur, R. L.
Amin, F.
Bitter, I.
Black, D.W.
Børglum, A.D.
Brown, M.A.
Bruggeman, R.
Buccola, N.G.
Cahn, W.
Cantor, R.M.
Carr, V.J.
Catts, S. V.
Choudhury, K.
Cloninger, C. R.
Cormican, P.
Danoy, P. A.
Datta, S.
DeHert, M.
Demontis, D.
Dikeos, D.
Donnelly, P.
Donohoe, G.
Duong, L.
Dwyer, S.
Fanous, A.
Fink-Jensen, A.
Freedman, R.
Freimer, N.B.
Friedl, M.
Georgieva, L.
Giegling, I.
Glenthoj, B.
Godard, S.
Golimbet, V.
de Haan, L.
Hansen, M.
Hansen, T.
Hartmann, A.M.
Henskens, F. A.
Hougaard, D. M.
Ingason, A.
Jablensky, A. V.
Jakobsen, K.D.
Jay, M.
Jönsson, E.G.
Jürgens, G.
Kahn, R.S.
Keller, M.C.
Kendler, K.S.
Kenis, G.
Kenny, E.
Konnerth, H.
Konte, B.
Krabbendam, L.
Krasucki, R.
Lasseter, V. K.
Laurent, C.
Lencz, T.
Lerer, F. B.
Liang, K. Y.
Lieberman, J. A.
Linszen, D.H.
Lönnqvist, J.
Loughland, C. M.
Maclean, A. W.
Maher, B.S.
Malhotra, A.K.
Mallet, J.
Malloy, P.
McGrath, J. J.
McLean, D. E.
Michie, P. T.
Milanova, V.
Mors, O.
Mortensen, P.B.
Mowry, B. J.
Myin-Germeys, I.
Neale, B.
Nertney, D. A.
Nestadt, G.
Nielsen, J.
Nordentoft, M.
Norton, N.
O'Neill, F.
Olincy, A.
Olsen, L.
Ophoff, R.A.
Orntoft, T. F.
van Os, J.
Pantelis, C.
Papadimitriou, G.
Pato, C.N.
Peltonen, L.
Pickard, B.
Pietilainen, O.P.
Pimm, J.
Pulver, A. E.
Puri, V.
Quested, D.
Rasmussen, H.B.
Rethelyi, J.M.
Ribble, R.
Riley, B.P.
Rossin, L.
Ruggeri, M.
Rujescu, D.
Schall, U.
Schwab, S. G.
Scott, R.J.
Silverman, J.M.
Spencer, C. C.
Strange, A.
Strengman, E.
Stroup, T.S.
Suvisaari, J.
Terenius, L.
Thirumalai, S.
Timm, S.
Toncheva, D.
Tosato, S.
van den Oord, E.J.
Veldink, J.
Visscher, P.M.
Walsh, D.
Wang, A. G.
Werge, T.
Wiersma, D.
Wildenauer, D. B.
Williams, H.J.
Williams, N.M.
van Winkel, R.
Wormley, B.
Zammit, S.
Schork, N.J.
Andreassen, O.A.
Dale, A.M.

January 2013

Recent results indicate that genome-wide association studies (GWAS) have the potential to explain mu...

From genome to function by studying eQTLs

Westra, Harm-Jan
Franke, Lude

October 2014

Genome-wide association studies (GWASs) have shown a large number of genetic variants to be associat...

Fine scale mapping of genetic loci associated with human disease

Maller, J

January 2013

Genome-wide association studies (GWAS) use custom SNP arrays that provide ef- fective genetic covera...

From genome to function by studying eQTLs

Westra, Harm-Jan
Franke, Lude

October 2014

AbstractGenome-wide association studies (GWASs) have shown a large number of genetic variants to be ...

Use of NDA to detect coexpression.

J. Kenneth Baillie (177195)
Andrew Bretherick (4903141)
Christopher S. Haley (4903156)
Sara Clohisey (4747563)
Alan Gray (3276414)
Lucile P. A. Neyton (4903150)
Jeffrey Barrett (4903153)
Eli A. Stahl (229145)
Albert Tenesa (107674)
Robin Andersson (3501872)
J. Ben Brown (4903144)
Geoffrey J. Faulkner (481019)
Marina Lizio (185917)
Ulf Schaefer (237265)
Carsten Daub (3815110)
Masayoshi Itoh (15728)
Naoto Kondo (32868)
Timo Lassmann (14297)
Jun Kawai (13865)
Damian Mole (4903138)
Vladimir B. Bajic (8687)
Peter Heutink (39587)
Michael Rehli (18004)
Hideya Kawaji (13861)
Albin Sandelin (2089)
Harukazu Suzuki (15733)
Jack Satsangi (259264)
Christine A. Wells (200908)
Nir Hacohen (220591)
Thomas C. Freeman (4903147)
Yoshihide Hayashizaki (3101)
Piero Carninci (3015)
Alistair R. R. Forrest (185918)
David A. Hume (87441)

March 2018

<p>(a) A subset of regulatory elements is identified containing disease-associated SNPs. (b) The str...

All SNPs Are Not Created Equal: Genome-Wide Association Studies Reveal a Consistent Pattern of Enrichment among Functionally Annotated SNPs

Andrew J. Schork (407292)
Wesley K. Thompson (407291)
Phillip Pham (407350)
Ali Torkamani (237060)
J. Cooper Roddey (407293)
Patrick F. Sullivan (143608)
John R. Kelsoe (104920)
Michael C. O'Donovan (170200)
Helena Furberg (407351)
Nicholas J. Schork (176346)
Ole A. Andreassen (170286)
Anders M. Dale (127526)

April 2013

<div><p>Recent results indicate that genome-wide association studies (GWAS) have the potential to ex...

Article Allelic expression mapping across cellular lineages to establish impact of non-coding SNPs

Veronique Adoue
Alicia Schiavi
Nicholas Light
Jonas Carlsson Almlöf
Per Lundmark
Bing Ge
Tony Kwan
Maxime Caron
Lars Rönnblom
Chuan Wang
Shu-huang Chen
Alison H Goodall
Francois Cambien
Panos Deloukas
Willem H Ouweh
Ann-christine Syvänen
Tomi Pastinen

August 2016

Most complex disease-associated genetic variants are located in non-coding regions and are therefore...

Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease - Fig 5

J. Kenneth Baillie (177195)
Andrew Bretherick (4903141)
Christopher S. Haley (4903156)
Sara Clohisey (4747563)
Alan Gray (3276414)
Lucile P. A. Neyton (4903150)
Jeffrey Barrett (4903153)
Eli A. Stahl (229145)
Albert Tenesa (107674)
Robin Andersson (3501872)
J. Ben Brown (4903144)
Geoffrey J. Faulkner (481019)
Marina Lizio (185917)
Ulf Schaefer (237265)
Carsten Daub (3815110)
Masayoshi Itoh (15728)
Naoto Kondo (32868)
Timo Lassmann (14297)
Jun Kawai (13865)
Damian Mole (4903138)
Vladimir B. Bajic (8687)
Peter Heutink (39587)
Michael Rehli (18004)
Hideya Kawaji (13861)
Albin Sandelin (2089)
Harukazu Suzuki (15733)
Jack Satsangi (259264)
Christine A. Wells (200908)
Nir Hacohen (220591)
Thomas C. Freeman (4903147)
Yoshihide Hayashizaki (3101)
Piero Carninci (3015)
Alistair R. R. Forrest (185918)
David A. Hume (87441)

March 2018

<p><b>(a) Relationship between GWAS p-value for a SNP, and coexpression scores of individual promote...

Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease

J. Kenneth Baillie (177195)
Andrew Bretherick (4903141)
Christopher S. Haley (4903156)
Sara Clohisey (4747563)
Alan Gray (3276414)
Lucile P. A. Neyton (4903150)
Jeffrey Barrett (4903153)
Eli A. Stahl (229145)
Albert Tenesa (107674)
Robin Andersson (3501872)
J. Ben Brown (4903144)
Geoffrey J. Faulkner (481019)
Marina Lizio (185917)
Ulf Schaefer (237265)
Carsten Daub (3815110)
Masayoshi Itoh (15728)
Naoto Kondo (32868)
Timo Lassmann (14297)
Jun Kawai (13865)
Damian Mole (4903138)
Vladimir B. Bajic (8687)
Peter Heutink (39587)
Michael Rehli (18004)
Hideya Kawaji (13861)
Albin Sandelin (2089)
Harukazu Suzuki (15733)
Jack Satsangi (259264)
Christine A. Wells (200908)
Nir Hacohen (220591)
Thomas C. Freeman (4903147)
Yoshihide Hayashizaki (3101)
Piero Carninci (3015)
Alistair R. R. Forrest (185918)
David A. Hume (87441)

March 2018

<div><p>Genetic variants underlying complex traits, including disease susceptibility, are enriched w...

Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease.

J Kenneth Baillie
Andrew Bretherick
Christopher S Haley
Sara Clohisey
Alan Gray
Lucile P A Neyton
Jeffrey Barrett
Eli A Stahl
Albert Tenesa
Robin Andersson
J Ben Brown
Geoffrey J Faulkner
Marina Lizio
Ulf Schaefer
Carsten Daub
Masayoshi Itoh
Naoto Kondo
Timo Lassmann
Jun Kawai
Damian Mole
Vladimir B Bajic
Peter Heutink
Michael Rehli
Hideya Kawaji
Albin Sandelin
Harukazu Suzuki
Jack Satsangi
Christine A Wells
Nir Hacohen
Thomas C Freeman
Yoshihide Hayashizaki
Piero Carninci
Alistair R R Forrest
David A Hume

March 2018

Genetic variants underlying complex traits, including disease susceptibility, are enriched within th...

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Martin Kellner
Christina Kiel
Bernhard H. F. Weber

September 2021

Elucidating the role of genetic variation in the regulation of gene expression is key to understandi...

Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types.

Finucane, Hilary K
Reshef, Yakir A
Anttila, Verneri
Slowikowski, Kamil
Gusev, Alexander
Byrnes, Andrea
Gazal, Steven
Loh, Po-Ru
Lareau, Caleb
Shoresh, Noam
Genovese, Giulio
Saunders, Arpiar
Macosko, Evan
Pollack, Samuela
Brainstorm Consortium
Perry, John
Buenrostro, Jason D
Bernstein, Bradley E
Raychaudhuri, Soumya
McCarroll, Steven
Neale, Benjamin M
Price, Alkes L

April 2018

We introduce an approach to identify disease-relevant tissues and cell types by analyzing gene expre...

All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs

Schork, AJ
Thompson, WK
Pham, P
Torkamani, A
Roddey, JC
Sullivan, PF
Kelsoe, JR
O’Donovan, MC
Furberg, H
The Tobacco and Genetics Consortium
Schizophrenia Psychiatric Genomics Consortium
The Bipolar Disorder Psychiatric Genomics Consortium
Schork, NJ
Andreassen, OA
Dale, AM

April 2013

Recent results indicate that genome-wide association studies (GWAS) have the potential to explain mu...

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Florian Uhle (250479)
Christoph Lichtenstern (707424)
Benedikt H. Siegler (707425)
Sabin Bhuju (107606)
Michael Jarek (166845)
Marek Bartkuhn (31889)
Markus A. Weigand (535137)

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<p>A) Heat map indicates result of un-supervised hierarchical clustering for 743 gene promoters with...

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Irit Gat-Viks (48213)

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<p>(<b>A</b>) A simple reference data. Shown are three cell types (<i>c1-c3</i>, left to right); eac...

All SNPs are not created equal: Genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs

Schork, A.J.
Thompson, W.K.
Pham, P.
Torkamani, A.
Roddey, J.C.
Sullivan, P.F.
Kelsoe, J.
O'Donovan, M.C.
Furberg, H.
Absher, D.
Agudo, A.
Almgren, P.
Ardissino, D.
Assimes, T.L.
Bandinelli, S.
Barzan, L.
Bencko, V.
Benhamou, S.
Benjamin, E.J.
Bernardinelli, L.
Bis, J.
Boehnke, M.
Boerwinkle, E.
Boomsma, D.I.
Brennan, P.
Canova, C.
Castellsagué, X.
Chanock, S.
Chasman, D.I.
Conway, D.I.
Dackor, J.
de Geus, E.J.C.
Duan, J.
Elosua, R.
Everett, B.
Fabianova, E.
Ferrucci, L.
Foretova, L.
Fortmann, S.P.
Franceschini, N.
Frayling, T.M.
Furberg, C.
Gejman, P.V.
Groop, L.
Gu, F.
Guralnik, J.
Hankinson, S.E.
Haritunians, T.
Healy, C.
Hofman, A.
Holcátová, I.
Hunter, D.J.
Hwang, S.J.
Ioannidis, J.P.A.
Iribarren, C.
Jackson, A.U.
Janout, V.
Kaprio, J.
Kim, Y.
Kjaerheim, K.
Knowles, J.W.
Kraft, P.
Ladenvall, C.
Lagiou, P.
Lanthrop, M.
Lerman, C.
Levinson, D.F.
Levy, D.
Li, M.D.
Lin, D.Y.
Lips, E.H.
Lissowska, J.
Lowry, R.B.
Lucas, G.
Macfarlane, T.V.
Maes, H.H.M.
Mannucci, P.M.
Mates, D.
Mauri, F.
McGovern, J.A.
McKay, J.D.
McKnight, B.
Melander, O.
Merlini, P.A.
Milaneschi, Y.
Mohlke, K.L.
O'Donnell, C.J.
Pare, G.
Penninx, B.W.J.H.
Perry, J.R.B.
Posthuma, D.
Preis, S.R.
Psaty, B.
Quertermous, T.
Ramachandran, V.S.
Richiardi, L.
Ridker, P.M.
Rose, J.
Rudnai, P.
Salomaa, V.
Sanders, A.R.
Schwartz, S.M.
Shi, J.
Smit, J.H.
Stringham, H.M.
Szeszenia-Dabrowska, N.
Tanaka, T.
Taylor, K.
Thacker, E.E.
Thornton, L.
Tiemeier, H.
Tuomilehto, J.
Uitterlinden, A.G.
van Duijn, C.M.
Vink, J.M.
Vogelzangs, N.
Voight, B.F.
Walter, S.
Willemsen, G.
Zaridze, D.
Znaor, A.
Akil, H.
Anjorin, A.
Backlund, L.
Badner, J.A.
Barchas, J.D.
Barrett, T.
Bass, N.
Bauer, M.
Bellivier, F.
Bergen, S.E.
Berrettini, W.
Blackwood, D.
Bloss, C.S.
Breen, G.
Breuer, R.
Bunner, W.E.
Burmeister, M.
Byerley, W. F.
Caesar, S.
Chambert, K.
Cichon, S.
St Clair, D.
Collier, D.A.
Corvin, A.
Coryell, W.H.
Craddock, N.
Craig, D.W.
Daly, M.
Day, R.
Degenhardt, F.
Djurovic, S.
Dudbridge, F.
Edenberg, H.J.
Elkin, A.
Etain, B.
Farmer, A.E.
Ferreira, M.A.
Ferrier, I.
Flickinger, M.
Foroud, T.
Frank, J.
Fraser, C.
Frisén, L.
Gershon, E.S.
Gill, M.
Gordon-Smith, K.
Green, E.K.
Greenwood, T.A.
Grozeva, D.
Guan, W.
Gurling, H.
Gustafsson, O.
Hamshere, M.L.
Hautzinger, M.
Herms, S.
Hipolito, M.
Holmans, P.A.
Hultman, C. M.
Jamain, S.
Jones, E.G.
Jones, I.
Jones, L.
Kandaswamy, R.
Kennedy, J.L.
Kirov, G. K.
Koller, D.L.
Kwan, P.
Landén, M.
Langstrom, N.
Lathrop, M.
Lawrence, J.
Lawson, W.B.
Leboyer, M.
Lee, P.H.
Li, J.
Lichtenstein, P.
Lin, D.
Liu, C.
Lohoff, F.W.
Lucae, S.
Mahon, P.B.
Maier, W.
Martin, N.G.
Mattheisen, M.
Matthews, K.
Mattingsdal, M.
McGhee, K.A.
McGuffin, P.
McInnis, M.G.
McIntosh, A.
McKinney, R.
McLean, A.W.
McMahon, F.J.
McQuillin, A.
Meier, S.
Melle, I.
Meng, F.
Mitchell, P.B.
Montgomery, G.W.
Moran, J.
Morken, G.
Morris, D.W.
Moskvina, V.
Muglia, P.
Mühleisen, T.W.
Muir, W.J.
Müller-Myhsok, B.
Myers, R.M.
Nievergelt, C.M.
Nikolov, I.
Nimgaonkar, V.L.
Nöthen, M.M.
Nurnberger, J.I.
Nwulia, E.A.
O'Dushlaine, C.
Osby, U.
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Owen, M.J.
Petursson, H.
Pickard, B.S.
Porgeirsson, P.
Potash, J.B.
Propping, P.
Purcell, S.M.
Quinn, E.
Raychaudhuri, S.
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Schalling, M.
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Scheftner, W.A.
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Scolnick, E.
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Stefansson, H.
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Steffens, M
Steinberg, S.
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Loughland, C. M.
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McGrath, J. J.
McLean, D. E.
Michie, P. T.
Milanova, V.
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Myin-Germeys, I.
Neale, B.
Nertney, D. A.
Nestadt, G.
Nielsen, J.
Nordentoft, M.
Norton, N.
O'Neill, F.
Olincy, A.
Olsen, L.
Ophoff, R.A.
Orntoft, T. F.
van Os, J.
Pantelis, C.
Papadimitriou, G.
Pato, C.N.
Peltonen, L.
Pickard, B.
Pietilainen, O.P.
Pimm, J.
Pulver, A. E.
Puri, V.
Quested, D.
Rasmussen, H.B.
Rethelyi, J.M.
Ribble, R.
Riley, B.P.
Rossin, L.
Ruggeri, M.
Rujescu, D.
Schall, U.
Schwab, S. G.
Scott, R.J.
Silverman, J.M.
Spencer, C. C.
Strange, A.
Strengman, E.
Stroup, T.S.
Suvisaari, J.
Terenius, L.
Thirumalai, S.
Timm, S.
Toncheva, D.
Tosato, S.
van den Oord, E.J.
Veldink, J.
Visscher, P.M.
Walsh, D.
Wang, A. G.
Werge, T.
Wiersma, D.
Wildenauer, D. B.
Williams, H.J.
Williams, N.M.
van Winkel, R.
Wormley, B.
Zammit, S.
Schork, N.J.
Andreassen, O.A.
Dale, A.M.

January 2013

Recent results indicate that genome-wide association studies (GWAS) have the potential to explain mu...

From genome to function by studying eQTLs

Westra, Harm-Jan
Franke, Lude

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Genome-wide association studies (GWASs) have shown a large number of genetic variants to be associat...

Fine scale mapping of genetic loci associated with human disease

Maller, J

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Genome-wide association studies (GWAS) use custom SNP arrays that provide ef- fective genetic covera...

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Westra, Harm-Jan
Franke, Lude

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AbstractGenome-wide association studies (GWASs) have shown a large number of genetic variants to be ...

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Eli A. Stahl (229145)
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Robin Andersson (3501872)
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Ulf Schaefer (237265)
Carsten Daub (3815110)
Masayoshi Itoh (15728)
Naoto Kondo (32868)
Timo Lassmann (14297)
Jun Kawai (13865)
Damian Mole (4903138)
Vladimir B. Bajic (8687)
Peter Heutink (39587)
Michael Rehli (18004)
Hideya Kawaji (13861)
Albin Sandelin (2089)
Harukazu Suzuki (15733)
Jack Satsangi (259264)
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Yoshihide Hayashizaki (3101)
Piero Carninci (3015)
Alistair R. R. Forrest (185918)
David A. Hume (87441)

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<p>(a) A subset of regulatory elements is identified containing disease-associated SNPs. (b) The str...

All SNPs Are Not Created Equal: Genome-Wide Association Studies Reveal a Consistent Pattern of Enrichment among Functionally Annotated SNPs

Andrew J. Schork (407292)
Wesley K. Thompson (407291)
Phillip Pham (407350)
Ali Torkamani (237060)
J. Cooper Roddey (407293)
Patrick F. Sullivan (143608)
John R. Kelsoe (104920)
Michael C. O'Donovan (170200)
Helena Furberg (407351)
Nicholas J. Schork (176346)
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<div><p>Recent results indicate that genome-wide association studies (GWAS) have the potential to ex...

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Veronique Adoue
Alicia Schiavi
Nicholas Light
Jonas Carlsson Almlöf
Per Lundmark
Bing Ge
Tony Kwan
Maxime Caron
Lars Rönnblom
Chuan Wang
Shu-huang Chen
Alison H Goodall
Francois Cambien
Panos Deloukas
Willem H Ouweh
Ann-christine Syvänen
Tomi Pastinen

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Most complex disease-associated genetic variants are located in non-coding regions and are therefore...

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Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease - Fig 3

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