Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease - Fig 5

<p><b>(a) Relationship between GWAS p-value for a SNP, and coexpression scores of individual promoters assigned to that SNP for all phenotypes for which significant coexpression was detected.</b> Top panel: GWAS p-values (log scale) vs corrected coexpression scores. Bottom panel: linear regression lines for data in top panel; Spearman's r and associated p-values are shown for each trait. Only significantly coexpressed (FDR<0.05) promoters are included. (b) Rank comparison of named genes compared with gene-level burden of significance in original GWAS studies (PASCAL sum genescore). Log rank is shown on each axis (Rank 1 = highest scoring gene) for the subset of coexpression scores obtained for promoters of named genes. Open squares indicate significant coexpression (FDR<0.05).