Driver gene–methylation associations and CpG subsets.

<p>(A) The total number of probes associated with any driver gene is shown for each cancer type (<i>top of each column</i>). Each point represents the fraction of corresponding probes associated with a driver gene (y-axis). Names are shown for each of the top three driver genes if they account for more than 10% of total probes (<i>dotted line</i>). See <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005840#pcbi.1005840.t001" target="_blank">Table 1</a> for cancer type abbreviations. (B) Driver genes with the most probe associations in each cancer type (<i>gene names in panel</i>). The bar plots show the proportion of associated probes in each of the three CpG subsets [CpG islands (CGIs), shores and shelves (SSs), or open sea], stratified by the direction of association (+/-). Dashed lines indicate the divisions expected if associations were proportionally distributed. No probes were associated with driver genes in BLCA, LUSC, and READ.