Driver gene–associated methylation patterns can be used to identify tumor molecular subtypes.

<p>Heat maps for (A) thyroid carcinoma (THCA) and (B) uterine corpus endometrial carcinoma (UCEC) depict hierarchical clustering of methylation values of the union set of the 500 probes most significantly associated with each of the three dominant driver genes in each cancer type. Each column represents a sample, and each row represents a probe. Mutation status and subtype classification are shown in the upper sidebars. The sidebars on the left indicate gene-probe associations and CpG subsets, as well as average methylation levels across normal samples. The arrow in (B) indicates methylation probes that display more hypomethylation in samples where <i>PTEN</i> and <i>CTNNB1</i> mutations co-occur than in samples with <i>PTEN</i> mutations alone.