Distribution of average gravitation (ave<i>G</i>) score for cancer driver genes (Driver), essential genes (Essential), and all genes (All) across 23 human chromosomes in 3 cancer types.

<p>The left plots show the distribution of ave<i>G</i> scores for three different genes across 23 human chromosomes in (<b>A</b>) BRCA: breast invasive carcinoma, (<b>B</b>) GBM: glioblastoma multiforme, and (<b>C</b>) UCEC: uterine corpus endometrial carcinoma. The right box plots show the comparison of ave<i>G</i> scores between the X chromosome (ChrX) and all the 22 autosomes (Autosomes) for three different gene sets in the corresponding left three cancer types. The p-values are calculated by the Wilcoxon rank-sum test and corrected by Benjamini-Hochberg multiple testing. The remaining 6 cancer types are provided in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004497#pcbi.1004497.s017" target="_blank">S17 Fig</a>.