Combined effects of genetic and epigenetic alterations.

<p>The left Venn diagrams show the relationship between cancer driver genes and (<b>A</b>) chromatin regulation factors (CRFs) and (<b>B</b>) DNA repair genes. The right panels show the distributions of the average gravitation (ave<i>G</i>) score of three gene sets in the corresponding left Venn diagram across 9 cancer types: (<b>A</b>) comparison of CRF cancer driver genes, non-CRF cancer driver genes, and non-driver CRF genes; (<b>B</b>) comparison of DNA repair cancer driver genes, non-DNA repair cancer driver genes, and non-driver DNA repair genes. The adjusted p-values (<i>q</i>) are calculated by the Wilcoxon rank-sum test and corrected by Benjamini-Hochberg multiple testing. The detailed data is provided in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004497#pcbi.1004497.s032" target="_blank">S5</a> and <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004497#pcbi.1004497.s034" target="_blank">S7</a> and <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004497#pcbi.1004497.s035" target="_blank">S8</a> Tables.