FIGURE 3 from Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment

NLRP3 inhibition reduces PDAC progression. A, Tumor volume and weight in WT and Nlrp3−/− mice (n = 8/group). B, Tumor volume and weight in mice fed standard (STD) or OL1177 (OLT) diet (n = 16/group). C, Survival curve in mice fed standard or OLT1177 diet (n = 20/group). D, Flow cytometry analysis of CD8, CD8/PD1, CD8/CD44/PD-1 cells in primary tumors of mice in B (n = 5/group). E, Flow cytometry analysis of memory (CD62L+/CD44+), naïve (CD62L+/CD44−), and effector (CD62L−/CD44+) CD8 cells in primary tumors of mice in D–F (n = 5/group). F, Gene expression of Ifng, Prf1, and Gzmb in primary tumors of mice in B (n = 5/group). Data expressed as mean ± SEM; ****, P P P < 0.05.