FIGURE 7 from Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment
- Jesus Amo-Aparicio (17013541)
- Adrian Dominguez (17013544)
- Shaikh M. Atif (17013547)
- Alberto Dinarello (17013550)
- Tania Azam (17013553)
- Kibrom M. Alula (17013556)
- Miles Piper (15035907)
- Christopher H. Lieu (15018279)
- Robert W. Lentz (17013559)
- Alexis D. Leal (17013562)
- Stacey M. Bagby (17013565)
- Wells A. Messersmith (17013568)
- Sana D. Karam (17013571)
- Charles A. Dinarello (17013574)
- Todd M. Pitts (17013577)
- Carlo Marchetti (17013580)
Publication date
September 2023
DOIAbstract
CSF-1R engagement induces NLRP3 activation in vivo. A, Tumor volume and weight in mice treated with α-CSF-1R or matching IgG (n = 6/group). B, Immunofluorescence staining from NLRP3 (red) and ASC (green) in primary tumors treated with α-CSF-1R or matching IgG (n = 3/group). C, Quantification of speck-like structure in mice treated with α-CSF-1R or matching IgG (n = 3/group). D, Schematic graphic representation of the proposed NLRP3 activation and signaling in PDAC (created with BioRender.com).</p
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