Fig. 4. Inhibitory effects of ABAQ on cAMP-induced chloride secretion in T84 cells. (A) Dose response studies of ABAQ on cAMP-induced chloride secretion. The representative traces of apical ISC on T84 cells is shown. (B) Data were fitted to the Hill equation and expressed as means of %forskolin-stimulated ISC ± S.E.M. (n = 3).Published as part of Dawurung, Christiana J., Noitem, Rattikarn, Rattanajak, Roonglawan, Bunyong, Ratchanu, Richardson, Christopher, Willis, Anthony C., Kamchonwongpaisan, Sumalee, Yimnual, Chantapol, Muanprasat, Chatchai & Pyne, Stephen G., 2020, Isolation of CFTR and TMEM16A inhibitors from Neorautanenia mitis (A. Rich) Verdcourt: Potential lead compounds for treatment of secretory diarrhea, pp. 1-11 in Phytochemistr...
The widely conserved cyclic adenosine monophosphate (cAMP) signaling pathway governs multiple physio...
(A) Effect of α,β-dehydrolovastatin (DHLV), lovastatin, α,β-dehydrodihydromonacolin K, mevastatin, s...
Despite the current management options and therapeutics used in the treatment of diarrhoea, in Afric...
Fig. 3. Inhibitory effects of compounds 2, 6, 7 and 10 on cAMP-induced chloride secretion in T84 cel...
Fig. 7. Effect of compound 10 on CFTR-mediated apical IClˉ in T84 cells. (A) The representative trac...
Fig. 5. Validation of TMEM16A activation in Calu-3 cells. (A) Representative traces of change in Cl ...
Fig. 6. ABDCM dose-dependently inhibited TMEM16A in Calu-3 cells. (A) Representative trace of change...
Fig. 8. No involvement of protein phosphatase and MRP4 in the inhibition of CFTR chloride channel ac...
Fig. 9. Effect of compound 10 on intestinal CaCC activity. (A) Representative trace of apical IClˉ. ...
Fig. 10. Anti-diarrheal application of compound 10 (A) Effect of compound 10 on CT-induced chloride ...
Dawurung, Christiana J., Noitem, Rattikarn, Rattanajak, Roonglawan, Bunyong, Ratchanu, Richardson, C...
Fig. 1. Chemical structures compounds 1–20.Published as part of Dawurung, Christiana J., Noitem, Rat...
Oriental herbal medicine with the two bioactive constituents, β-eudesmol (BE) and atractylodin (AT),...
(A) Schematic diagrams showing the regulatory mechanism of CFTR Cl- channel activity. (B) Effect of ...
<p>A. Krisanaklan, a commonly used Thai herbal antidiarrheal remedy. B. Short-circuit measurement in...
The widely conserved cyclic adenosine monophosphate (cAMP) signaling pathway governs multiple physio...
(A) Effect of α,β-dehydrolovastatin (DHLV), lovastatin, α,β-dehydrodihydromonacolin K, mevastatin, s...
Despite the current management options and therapeutics used in the treatment of diarrhoea, in Afric...
Fig. 3. Inhibitory effects of compounds 2, 6, 7 and 10 on cAMP-induced chloride secretion in T84 cel...
Fig. 7. Effect of compound 10 on CFTR-mediated apical IClˉ in T84 cells. (A) The representative trac...
Fig. 5. Validation of TMEM16A activation in Calu-3 cells. (A) Representative traces of change in Cl ...
Fig. 6. ABDCM dose-dependently inhibited TMEM16A in Calu-3 cells. (A) Representative trace of change...
Fig. 8. No involvement of protein phosphatase and MRP4 in the inhibition of CFTR chloride channel ac...
Fig. 9. Effect of compound 10 on intestinal CaCC activity. (A) Representative trace of apical IClˉ. ...
Fig. 10. Anti-diarrheal application of compound 10 (A) Effect of compound 10 on CT-induced chloride ...
Dawurung, Christiana J., Noitem, Rattikarn, Rattanajak, Roonglawan, Bunyong, Ratchanu, Richardson, C...
Fig. 1. Chemical structures compounds 1–20.Published as part of Dawurung, Christiana J., Noitem, Rat...
Oriental herbal medicine with the two bioactive constituents, β-eudesmol (BE) and atractylodin (AT),...
(A) Schematic diagrams showing the regulatory mechanism of CFTR Cl- channel activity. (B) Effect of ...
<p>A. Krisanaklan, a commonly used Thai herbal antidiarrheal remedy. B. Short-circuit measurement in...
The widely conserved cyclic adenosine monophosphate (cAMP) signaling pathway governs multiple physio...
(A) Effect of α,β-dehydrolovastatin (DHLV), lovastatin, α,β-dehydrodihydromonacolin K, mevastatin, s...
Despite the current management options and therapeutics used in the treatment of diarrhoea, in Afric...