Fig. 8 in Isolation of CFTR and TMEM16A inhibitors from Neorautanenia mitis (A. Rich) Verdcourt: Potential lead compounds for treatment of secretory diarrhea

  • Dawurung, Christiana J.
  • Noitem, Rattikarn
  • Rattanajak, Roonglawan
  • Bunyong, Ratchanu
  • Richardson, Christopher
  • Willis, Anthony C.
  • Kamchonwongpaisan, Sumalee
  • Yimnual, Chantapol
  • Muanprasat, Chatchai
  • Pyne, Stephen G.
Publication date
November 2020

Abstract

Fig. 8. No involvement of protein phosphatase and MRP4 in the inhibition of CFTR chloride channel activity by compound 10 (A) Representative trace of apical IClˉ stimulation after pretreatment with Na3VO4 (protein phosphatase inhibitor; 1 mM) and MK571 (MRP4 inhibitor; 20 μM). (B) Data were fitted to the Hill equation and expressed as means of %forskolin-stimulated IClˉ ± S.E.M. (n = 3).Published as part of Dawurung, Christiana J., Noitem, Rattikarn, Rattanajak, Roonglawan, Bunyong, Ratchanu, Richardson, Christopher, Willis, Anthony C., Kamchonwongpaisan, Sumalee, Yimnual, Chantapol, Muanprasat, Chatchai & Pyne, Stephen G., 2020, Isolation of CFTR and TMEM16A inhibitors from Neorautanenia mitis (A. Rich) Verdcourt: Potential lead compounds ...

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