Fig. 8. No involvement of protein phosphatase and MRP4 in the inhibition of CFTR chloride channel activity by compound 10 (A) Representative trace of apical IClˉ stimulation after pretreatment with Na3VO4 (protein phosphatase inhibitor; 1 mM) and MK571 (MRP4 inhibitor; 20 μM). (B) Data were fitted to the Hill equation and expressed as means of %forskolin-stimulated IClˉ ± S.E.M. (n = 3).Published as part of Dawurung, Christiana J., Noitem, Rattikarn, Rattanajak, Roonglawan, Bunyong, Ratchanu, Richardson, Christopher, Willis, Anthony C., Kamchonwongpaisan, Sumalee, Yimnual, Chantapol, Muanprasat, Chatchai & Pyne, Stephen G., 2020, Isolation of CFTR and TMEM16A inhibitors from Neorautanenia mitis (A. Rich) Verdcourt: Potential lead compounds ...
Despite the current management options and therapeutics used in the treatment of diarrhoea, in Afric...
The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a cAMP-activated chloride channel ...
Inhibitors of cystic fibrosis transmembrane conductance regulator (CFTR) have been widely used for c...
Fig. 7. Effect of compound 10 on CFTR-mediated apical IClˉ in T84 cells. (A) The representative trac...
Fig. 5. Validation of TMEM16A activation in Calu-3 cells. (A) Representative traces of change in Cl ...
Fig. 9. Effect of compound 10 on intestinal CaCC activity. (A) Representative trace of apical IClˉ. ...
Dawurung, Christiana J., Noitem, Rattikarn, Rattanajak, Roonglawan, Bunyong, Ratchanu, Richardson, C...
Fig. 3. Inhibitory effects of compounds 2, 6, 7 and 10 on cAMP-induced chloride secretion in T84 cel...
Fig. 1. Chemical structures compounds 1–20.Published as part of Dawurung, Christiana J., Noitem, Rat...
Fig. 6. ABDCM dose-dependently inhibited TMEM16A in Calu-3 cells. (A) Representative trace of change...
Fig. 10. Anti-diarrheal application of compound 10 (A) Effect of compound 10 on CT-induced chloride ...
Fig. 4. Inhibitory effects of ABAQ on cAMP-induced chloride secretion in T84 cells. (A) Dose respons...
Cystic fibrosis transmembrane conductance regulator (CFTR) is the principal apical route for transep...
Cystic fibrosis transmembrane conductance regulator (CFTR) is an unusual ABC transporter. It acts as...
Secretory diarrhea remains a major health challenge worldwide. Excessive fluid secretion in the inte...
Despite the current management options and therapeutics used in the treatment of diarrhoea, in Afric...
The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a cAMP-activated chloride channel ...
Inhibitors of cystic fibrosis transmembrane conductance regulator (CFTR) have been widely used for c...
Fig. 7. Effect of compound 10 on CFTR-mediated apical IClˉ in T84 cells. (A) The representative trac...
Fig. 5. Validation of TMEM16A activation in Calu-3 cells. (A) Representative traces of change in Cl ...
Fig. 9. Effect of compound 10 on intestinal CaCC activity. (A) Representative trace of apical IClˉ. ...
Dawurung, Christiana J., Noitem, Rattikarn, Rattanajak, Roonglawan, Bunyong, Ratchanu, Richardson, C...
Fig. 3. Inhibitory effects of compounds 2, 6, 7 and 10 on cAMP-induced chloride secretion in T84 cel...
Fig. 1. Chemical structures compounds 1–20.Published as part of Dawurung, Christiana J., Noitem, Rat...
Fig. 6. ABDCM dose-dependently inhibited TMEM16A in Calu-3 cells. (A) Representative trace of change...
Fig. 10. Anti-diarrheal application of compound 10 (A) Effect of compound 10 on CT-induced chloride ...
Fig. 4. Inhibitory effects of ABAQ on cAMP-induced chloride secretion in T84 cells. (A) Dose respons...
Cystic fibrosis transmembrane conductance regulator (CFTR) is the principal apical route for transep...
Cystic fibrosis transmembrane conductance regulator (CFTR) is an unusual ABC transporter. It acts as...
Secretory diarrhea remains a major health challenge worldwide. Excessive fluid secretion in the inte...
Despite the current management options and therapeutics used in the treatment of diarrhoea, in Afric...
The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a cAMP-activated chloride channel ...
Inhibitors of cystic fibrosis transmembrane conductance regulator (CFTR) have been widely used for c...