A STUDY ON COMPARISON OF LIPID PROFILE IN DIABETIC AND NON-DIABETIC PATIENTS WITH ISCHEMIC HEART DISEASE

Introduction: Cardio Vascular Disease (CVD) is a leading cause of death in the world. In Sri Lanka 40 % of proportional mortality is due to CVD. South Asians are susceptible to Acute Myocardial Infarction (AMI) at an earlier age as they tend to develop higher risk-factor levels much earlier in life. Aims and objectives: The basic aim of the study was to analyze the lipid profile in diabetic and non-diabetic patients with ischemic heart disease. This study was done in the local population of Pakistan. Material and methods: This cross sectional study was conducted in DHQ Hospital Khanewal during 2018 to 2019.The data was collected from 100 patients of both genders. The data were collected through randomly selected sampling technique. There were two groups of study one was suffering from diabetes and one was non diabetic patients. Diagnosed cases of diabetic and non-diabetic atherosclerotic patients were included after obtaining a written consent from their care takers to take part in the study. Questionnaires were duly filled in with bio-data of the patients, clinical presentation of the illness, complete blood count record, along with available additional investigative information. Results: The data were collected from 100 patients. The study subjects were divided: on the basis of health condition into normal, N group; non-diabetic and atherosclerotic, NA group; and diabetic and atherosclerotic, DA group. Irrespective of statin therapy the Lp(a) concentration was not significantly different among males or females and was higher than 45 mg/dL. The average TC and LDLc were within the normal range irrespective of Lp(a) being above 30 mg/dL (upper limit reagent kit) or more than 25 mg/dL as suggested cutoff. Conclusion: It is concluded that comparison of lipid profile in non-diabetic and diabetic atherosclerosis patients would enable us to maintain the health of patients by reducing cardiovascular risk