Distribution of mutations, pathway activation, and methylation profiles in cancer cell state map.

(A) Distribution of common breast cancer mutations including PIK3CA (left), TP53 (middle), and TTN (right). The density is represented as less dense (blue) to denser (red). (B) The activation of the EGFR, Estrogen, and hypoxia pathways are also projected on the ternary graph. For each pathway, the tumors with the highest activation score are plotted. (C) Methylation patterns of GRB7, MMP7, and GSTP1. The 25 tumors with the highest average methylation scores across all loci in each gene are plotted on the cancer cell state map. Figure components created with BioRender.com.