Figure 1 from β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer

Loss of Btnl1 increases adenoma formation in Apc-deficient mouse models. A, Images of SI from VA and VA;Btnl1—/— mice stained for Btnl1 mRNA representative of 4/group; scale bar, 100 μm. B, Images of SI from VA and VA;Btnl1—/— mice stained for Trdc mRNA; scale bar, 500 μm. γδ T-cell numbers in SI of indicated models. Each dot represents one mouse (n = 3). C, Kaplan–Meier survival analysis of VA (n = 15) and VA;Btnl1—/— (n = 6) mice. D, Tumor number and tumor burden (mm2) in SI and colon of VA and VA;Btnl1—/— mice. Each dot represents one mouse (n = 15 VA, 6 VA;Btnl1—/— mice). Data are presented as mean ± SD. *, P P t test).