Representative histopathology of the mouse liver at the end of Week 63.

Low-power original magnification ×40 (A1, B1, and C1). High-power original magnification ×200 (A2, B2, and C2). Severe lobular inflammation, fibrosis, and numerous foamy macrophages were observed in the liver samples of mice fed with CDAA-HF-T(−) but not of those fed with the control diet. Comparison of Sirius Red-stained areas in control, nontumoral liver area and tumoral liver area of the CDAA-HF-T(−) (D). Results are expressed as percentage of section staining (+) for Sirius Red. *Significantly different from the control group value. #Significantly different from the CDAA-HF-T(−)-Non tumor value.