Profiles of vacuolation scores of animals inoculated with samples containing A. Shaking-propagated Mo recPrPSc prions, B. PMCA-propagated Mo recPrPSc molecules, or C. input prions. Prion strains: Me7 = blue circles, 301C = red triangles. Brain regions: CC = cerebral cortex (all layers), H = hippocampus, T = Thalamus, HT = Hypothalamus, Mid = Midbrain, BS = brain stem, Cb = cerebellum. The mean values (n = 4–8) are shown ± S.E.M.</p
Although prion diseases are most commonly modeled using the laboratory mouse, the diversity of prion...
<p>(<b>A</b>) The expression levels of microglia (AIF1) and astrocyte (GFAP) cell markers determined...
Regions of each brain corresponding to the dorsal lateral geniculate nucleus, hypothalamus, and vent...
<p>(A) Survival curves of <i>Tg</i>a20 and WT mice IC inoculated with prions indicate that strains i...
(A) Hematoxylin/eosin stained sections from the cerebella of prion-inoculated (RML6) terminally sick...
<p>(<b>A</b>) First column: Paraffin-embedded tissue (PET) blots demonstrating PrP<sup>Sc</sup> depo...
A Spongiosis and PrPSc deposition profiles. Spongiform lesions and PrPSc deposition were evaluated s...
Images of specific brain regions in hematoxylin- & eosin-stained brain sections taken from mice inoc...
<p>Panels A, E, I and M, schematics showing regional distribution of abnormal PrP deposits. Note tha...
<p>(A) Lesion profiles of first-passage TgBoPrP mice inoculated with H-BSE from cattle (H-BSE/cattle...
<p>Patterns of PrP<sup>Sc</sup> deposition in the brain following first (left column) and second (ri...
<p>(A) Spongiosis is milder in the cerebral cortex, hippocampus, thalamus and cerebellum from 22L-in...
<p>(A) WT mice. Survival curves and PrP<sup>Sc</sup>-immunolabelled brain sections indicate that 22 ...
<p>Brain lesion profiles and PrP<sup>d</sup> deposition profiles represent the mean semi-quantitativ...
<p>Spongiosis in the following brain regions were scored. Grey matter regions: G1, dorsal medulla; G...
Although prion diseases are most commonly modeled using the laboratory mouse, the diversity of prion...
<p>(<b>A</b>) The expression levels of microglia (AIF1) and astrocyte (GFAP) cell markers determined...
Regions of each brain corresponding to the dorsal lateral geniculate nucleus, hypothalamus, and vent...
<p>(A) Survival curves of <i>Tg</i>a20 and WT mice IC inoculated with prions indicate that strains i...
(A) Hematoxylin/eosin stained sections from the cerebella of prion-inoculated (RML6) terminally sick...
<p>(<b>A</b>) First column: Paraffin-embedded tissue (PET) blots demonstrating PrP<sup>Sc</sup> depo...
A Spongiosis and PrPSc deposition profiles. Spongiform lesions and PrPSc deposition were evaluated s...
Images of specific brain regions in hematoxylin- & eosin-stained brain sections taken from mice inoc...
<p>Panels A, E, I and M, schematics showing regional distribution of abnormal PrP deposits. Note tha...
<p>(A) Lesion profiles of first-passage TgBoPrP mice inoculated with H-BSE from cattle (H-BSE/cattle...
<p>Patterns of PrP<sup>Sc</sup> deposition in the brain following first (left column) and second (ri...
<p>(A) Spongiosis is milder in the cerebral cortex, hippocampus, thalamus and cerebellum from 22L-in...
<p>(A) WT mice. Survival curves and PrP<sup>Sc</sup>-immunolabelled brain sections indicate that 22 ...
<p>Brain lesion profiles and PrP<sup>d</sup> deposition profiles represent the mean semi-quantitativ...
<p>Spongiosis in the following brain regions were scored. Grey matter regions: G1, dorsal medulla; G...
Although prion diseases are most commonly modeled using the laboratory mouse, the diversity of prion...
<p>(<b>A</b>) The expression levels of microglia (AIF1) and astrocyte (GFAP) cell markers determined...
Regions of each brain corresponding to the dorsal lateral geniculate nucleus, hypothalamus, and vent...