Comparison of mice inoculated with prion strains by intracerebral (IC) and intraperitoneal (IP) routes.

<p>(A) WT mice. Survival curves and PrP^Sc-immunolabelled brain sections indicate that 22 L prions cause terminal disease after either IC or IP exposure, whereas 87 V prions cause terminal disease only after IC exposure. Histoblots of spleen show PrP^Sc in the lymphoid follicles of 22 L, but not 87 V-inoculated mice. (B) <i>Tg</i>a20 mice. Survival curves and PrP^Sc-immunolabelled brain sections similarly show that RML prions cause terminal disease after either IC or IP exposure. mCWD prions cause terminal disease after IC and in some mice after IP exposure, suggesting inefficient neuroinvasion. Histoblots of spleen show PrP^Sc in the lymphoid follicles in RML-, and some mCWD-inoculated mice. Scale bar = 400 µm (brain) or 1 µm (spleen).