Highly disruptive variants in MMR and BER proteins in the NCBI Pathogen Detection Database.

Percentage calculations in “Number of assemblies” column represent the number of assemblies containing variants in the given gene divided by the number of assemblies with at least 1 high-similarity BLASTp match for all proteins in the DNA repair system (n = 6,805). The percentage calculations in “Number of variants” column represent the number of unique variants divided by the same denominator above. This latter percentage represents a conservative estimate of the variant frequency adjusted for clonality with the assumption that all assemblies containing a given variant are clonal. (DOCX)