Comparisons of variant frequencies in the NCI-60 to that in non-cancerous tissues (the ESP5400).

<p><b>A</b>. Scatter plot for all 84,861 variants that occur both in the NCI-60 and the ESP5400. The x-axis is the ratio of frequencies of variants in the NCI-60 vs. the frequencies of the same variants in the ESP5400. The y-axis is the number of the variants, ordered by the frequency ratio. The boxed “Enriched” variants (in the NCI-60) include 2,792 variants, and the boxed “Depleted” variants numbers 319. Enrichment is defined as the top 2.5% of variants for which the ratio of frequencies is ≥10. Depletion is defined as the bottom 2.5% of variants, for which the ratio of frequencies is ≤0.1. In both A and B, the vertical lines drawn at x = 1 indicate equal frequencies in the NCI-60 and non-cancerous genomes (ESP5400). <b>B</b>. Scatter plot for the protein-function-affecting variants that occur in both the NCI-60 and the non-cancerous genomes. The y-axis is the percent of protein function affecting amino-acid changing variants (as compared to all variants) within a sliding window of size 2001.