Phenotypic and mutational distribution of the cDNA clones.

<p>A) Fraction of cDNA clones found to be infectious, replication competent, or non-functional. B) Number of mutations of different types (silent, missense, insertion/deletion and untranslated region), in the three functional cDNA classes (infectious, replication competent, and non-functional). The average number per cDNA clone is shown; error bars depict standard deviations. Non-functional cDNAs were found to have significantly more missense mutations than infectious cDNAs (p = 3.3E-5, Student's t-test). They also displayed significantly more mutations in total (p = 0.0002).