Solid and dashed correspond to stable and unstable steady states. The solid circles denote the saddle-nodes (SN1-2, blue/orange dots) or pitchfork bifurcation points (PF, yellow dots). (TIF)</p
<p>(A) Wip1 synthesis rate <i>s</i><sub>1</sub> = 0.2, (B) <i>s</i><sub>1</sub> = 0.4. The stable an...
<p>Bifurcation diagram of the detailed genetic switch with fast protein-DNA binding/unbinding, The r...
<p>Red curves represent stable steady states and the black curves represent unstable steady states. ...
Solid and dashed lines correspond to the stable and unstable steady states. The solid circle marks s...
Solid and dashed lines correspond to the stable and unstable steady states. The solid circle marks s...
<p>The thick lines are stable steady states, the dashed lines are unstable steady states. (A). A loa...
Solid and dashed lines represent stable and unstable steady states of x1, respectively. Dots represe...
(A) Diagram of interaction between the toggle switch circuit and growth rate. (B) Nullcline analysis...
<p>The maximum and minimum numbers of protein R are plotted as a function of the R protein degradati...
(A) Nullcline analysis shows the emergence of quadstability. Red and blue lines represent the nullcl...
2 pages, 1 figureMotivation Multi-steady state behaviour, and in particular multi-stability, provid...
<p>(A) Bifurcation diagram of the system in Equation 1, an idealized model of a gene activated by si...
<p>The dependence of the steady states of variable <i>R</i><sub>c</sub> (RNA level of c-KIT) on para...
<p>The red circles and black squares on borderlines represent saddle-nodes and Hopf bifurcations, re...
High and low TGF-β signals (G) provide an on-off switch of N2 activation and determine the dichotomo...
<p>(A) Wip1 synthesis rate <i>s</i><sub>1</sub> = 0.2, (B) <i>s</i><sub>1</sub> = 0.4. The stable an...
<p>Bifurcation diagram of the detailed genetic switch with fast protein-DNA binding/unbinding, The r...
<p>Red curves represent stable steady states and the black curves represent unstable steady states. ...
Solid and dashed lines correspond to the stable and unstable steady states. The solid circle marks s...
Solid and dashed lines correspond to the stable and unstable steady states. The solid circle marks s...
<p>The thick lines are stable steady states, the dashed lines are unstable steady states. (A). A loa...
Solid and dashed lines represent stable and unstable steady states of x1, respectively. Dots represe...
(A) Diagram of interaction between the toggle switch circuit and growth rate. (B) Nullcline analysis...
<p>The maximum and minimum numbers of protein R are plotted as a function of the R protein degradati...
(A) Nullcline analysis shows the emergence of quadstability. Red and blue lines represent the nullcl...
2 pages, 1 figureMotivation Multi-steady state behaviour, and in particular multi-stability, provid...
<p>(A) Bifurcation diagram of the system in Equation 1, an idealized model of a gene activated by si...
<p>The dependence of the steady states of variable <i>R</i><sub>c</sub> (RNA level of c-KIT) on para...
<p>The red circles and black squares on borderlines represent saddle-nodes and Hopf bifurcations, re...
High and low TGF-β signals (G) provide an on-off switch of N2 activation and determine the dichotomo...
<p>(A) Wip1 synthesis rate <i>s</i><sub>1</sub> = 0.2, (B) <i>s</i><sub>1</sub> = 0.4. The stable an...
<p>Bifurcation diagram of the detailed genetic switch with fast protein-DNA binding/unbinding, The r...
<p>Red curves represent stable steady states and the black curves represent unstable steady states. ...