<p>The dependence of the steady states of variable <i>R</i><sub>c</sub> (RNA level of c-KIT) on parameter <i>k</i><sub>5</sub> (transcription rate of E2F6) for different values of <i>K</i><sub>4</sub>: (A) <i>K</i><sub>4</sub> = 0.1 (i.e., low inhibition efficiency of E2F6), (B) <i>K</i><sub>4</sub> = 1 (i.e., high inhibition efficiency of E2F6). The red and blue arrow line indicates abrupt shifts of the steady state of <i>R</i><sub>c</sub> with at different <i>k<sub>5</sub></i> values which indicated below. The value of parameters are listed in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0116050#pone.0116050.s005" target="_blank">S2 Text</a>.</p
<p>Set up initial conditions as , [E2F] = 1.1489, [MiR449] = 61.9160, [Myc] = 1.0084, [Cdk6] = 0.229...
Solid and dashed correspond to stable and unstable steady states. The solid circles denote the saddl...
<p>(A) Bifurcation diagram of the system in Equation 1, an idealized model of a gene activated by si...
<p>The dependence of the steady states of variable <i>R</i><sub>c</sub> (RNA level of c-KIT) on para...
<p><b>(A)</b> One-parameter bifurcation diagram. The transcription rate of the <i>Per2</i> mRNA is v...
<p>(A) Complete bifurcation diagram. Inset: detail of branches near . (B) Amplification of states re...
Solid and dashed lines correspond to the stable and unstable steady states. The solid circle marks s...
Solid and dashed lines correspond to the stable and unstable steady states. The solid circle marks s...
(A) Determination of steady states. Solid and dashed lines represent values of the RR production fun...
<p>The maximum and minimum numbers of protein R are plotted as a function of the R protein degradati...
<p>GF (growth factor) is the bifurcation parameter that is being changed. Red and blue curves are th...
<p>(A) Wip1 synthesis rate <i>s</i><sub>1</sub> = 0.2, (B) <i>s</i><sub>1</sub> = 0.4. The stable an...
<p>The phase diagrams (<i>r</i><sub>2</sub>×<i>r</i><sub>1</sub> plane) show the qualitative behavio...
<p>Dependence of the steady state values of all six components on A<sub><i>tot</i></sub>, (A) <i>k</...
<p><b>(a)</b> The effect of increasing the levels of mitogen on Rb hyper-phosphorylation. Filled cir...
<p>Set up initial conditions as , [E2F] = 1.1489, [MiR449] = 61.9160, [Myc] = 1.0084, [Cdk6] = 0.229...
Solid and dashed correspond to stable and unstable steady states. The solid circles denote the saddl...
<p>(A) Bifurcation diagram of the system in Equation 1, an idealized model of a gene activated by si...
<p>The dependence of the steady states of variable <i>R</i><sub>c</sub> (RNA level of c-KIT) on para...
<p><b>(A)</b> One-parameter bifurcation diagram. The transcription rate of the <i>Per2</i> mRNA is v...
<p>(A) Complete bifurcation diagram. Inset: detail of branches near . (B) Amplification of states re...
Solid and dashed lines correspond to the stable and unstable steady states. The solid circle marks s...
Solid and dashed lines correspond to the stable and unstable steady states. The solid circle marks s...
(A) Determination of steady states. Solid and dashed lines represent values of the RR production fun...
<p>The maximum and minimum numbers of protein R are plotted as a function of the R protein degradati...
<p>GF (growth factor) is the bifurcation parameter that is being changed. Red and blue curves are th...
<p>(A) Wip1 synthesis rate <i>s</i><sub>1</sub> = 0.2, (B) <i>s</i><sub>1</sub> = 0.4. The stable an...
<p>The phase diagrams (<i>r</i><sub>2</sub>×<i>r</i><sub>1</sub> plane) show the qualitative behavio...
<p>Dependence of the steady state values of all six components on A<sub><i>tot</i></sub>, (A) <i>k</...
<p><b>(a)</b> The effect of increasing the levels of mitogen on Rb hyper-phosphorylation. Filled cir...
<p>Set up initial conditions as , [E2F] = 1.1489, [MiR449] = 61.9160, [Myc] = 1.0084, [Cdk6] = 0.229...
Solid and dashed correspond to stable and unstable steady states. The solid circles denote the saddl...
<p>(A) Bifurcation diagram of the system in Equation 1, an idealized model of a gene activated by si...