Bifurcation diagram of p53_KILLER vs. PTEN mRNA synthesis rate (<i>s</i>₂).

<p>(A) Wip1 synthesis rate <i>s</i>₁ = 0.2, (B) <i>s</i>₁ = 0.4. The stable and unstable steady states are indicated by solid and dashed lines, respectively. Ranges of stable and unstable limit cycles are indicated by dark and light blue lines, respectively; dots and open circles are the maxima and minima of the stable and unstable limit cycles, respectively. Green vertical line in (A) shows Neimark—Sacker bifurcation (N—S). Red dots mark saddle-node bifurcations (SN₁, SN₂), orange dots mark supercritical Hopf (H_super) and subcritical Hopf (H_sub) bifurcations. The numbers in format <i>n</i>⁺ adjacent to the steady state lines denote the number of eigenvalues with the positive real parts. Notice the logarithmic scale on vertical axes.