Co-expression analysis in human exhausted T-cells.

(A) Analysis of a set of soft thresholding powers. The left panel is the scale free fit index as a function of soft thresholding power. The right panel is mean connectivity as a function of the soft thresholding power. (B) Heatmap of module and trait correlation. Module is marked by unique color labels. ME: module eigengene. (C) Eigengene dendrogram and heatmap between modules and the exhaustion trait. The top figure represents the hierarchical clustering dendrogram of MEs and exhaustion trait. The bottom figure shows the eigengene network heatmap plot of the adjacencies including exhaustion trait. Each row and column corresponds to one ME or exhaustion trait. Red color represents positive correlation, while blue represents negative correlation. (D) Scatterplot of gene significance for exhaustion trait (y-axis) vs. membership in a selected module (x-axis).