Stereoselective synthesis and conformational analysis of unnatural tetrapeptides. Part 2

Stereoselective synthesis of unnatural tetrapeptides containing two L-valine units and two unnatural alpha-amino acids (ornithine and modified aspartic acid), has been accomplished starting from a L-valine derived chiral synthon. Structural investigations of these non-proteinogenic peptides have been carried out on the acetamido derivatives using 1H-NMR, IR spectroscopic techniques and a conformational analysis based on molecular dynamics (MD) and cluster analysis