Stereoselective synthesis and conformational analysis of pseudo-heptapeptides. Part 5

The stereoselective synthesis of pseudo-heptapeptides incorporating 2,6-diamino-4-methylen-1,7-heptanedioic acid residue, was accomplished starting from a masked unnatural dipeptide derived from an L-valine unit and (2R)-methylaspartic acid. Investigations of the conformational preference and structure of these unnatural peptides were carried out using 1H-NMR and IR spectroscopic data and a conformational analysis based on molecular dynamics (MD)