Kaplan-Meier survival curves of mice treated with DMSO, TMZ, or TMZ and ABT-888.

Mice were implanted with BTICs from Groups I, II and III. Mice bearing BT067 (A), a Group I line, lived significantly longer after TMZ, but had no further survival benefit from the addition of ABT-888 to TMZ. Mice bearing BT030 (B), a Group II line, did not live longer after TMZ alone, but lived significantly longer after the addition of ABT-888 to TMZ. Mice bearing BT143 and BT088 (C, D), methylated lines from Group III, lived significantly longer after TMZ and longer still after the addition of ABT-888 to TMZ. Mice bearing the BT147 (E), a Group III unmethylated line, did not live significantly longer after TMZ, but had significantly longer survival after the addition of ABT-888 to TMZ. The log-rank (Mantel-Cox) test was used to compare survival curves (ns = p > 0.05; * = p < 0.05; ** = p < 0.01; *** = p < 0.001; **** = p < 0.0001).