MO treatment increases weight and survival rate in severe SMA mice.

<p>(A) Control mice gained weight as expected and MO treatment increased weight compared with untreated SMA mice. Control (blue; n = 34), Taiwanese severe SMA mice (red; n = 23), and Taiwanese severe SMA mice with MO treatment (green; n = 10). All quantitative data are presented as mean ± SEM. (B) Kaplan-Meier curves indicate a dramatic improvement in survival after treatment with MO in Taiwanese SMA severe mice. <i>P</i> < 0.05, log-rank test.