Combination metabolic therapy extends survival time in mice with metastatic cancer.

<p><b>(A)</b> Kaplan-Meier survival curve of study groups. KD, KD+KE, and KD+KE+HBOT treated mice demonstrated prolonged survival compared to controls (p = 0.03, p = 0.009, and p<0.0001, respectively; log-rank Mantel-Cox test for survival distribution). There was a strong trend of more prolonged survival in the combination treatment mice compared to KD or KD+KE, but these curves were not significantly different from each other (KD vs. KD+KE+HBOT p = 0.0622; KD+KE vs. KD+KE+HBOT p = 0.1924; log-rank Mantel-Cox test). <b>(B)</b> Cohort size (N), mean survival (days), and percent increase in mean survival time from control. KD, KD+KE, and KD+KE+HBOT treated mice exhibited a 44.6%, 65.4%, and 103.2% increase in mean survival time compared to controls, respectively (*p<0.05, **p<0.01, ***p<0.001; One-Way ANOVA). Similar to the survival curve analysis, there was a trend of increased mean survival time in combination treated mice compared to KD and KD+KE, but these differences were not significant (KD vs. KD+KE+HBOT p = 0.1062; KD+KE vs. KD+KE+HBOT p = 0.2763). Results were considered significant when p<0.05.