Facile Chemoselective Modification of Thio-Ethers Generates Chiral Center-Induced Helical Peptides
- Zhanfeng Hou (1623067)
- Chengjie Sun (1449106)
- Hao Geng (1530361)
- Kuan Hu (3349553)
- Mingsheng Xie (2031331)
- Yue Ma (384284)
- Fan Jiang (144211)
- Feng Yin (681489)
- Zigang Li (606370)
Publication date
September 2018
DOI Publisher
American Chemical Society (ACS)Abstract
A precisely positioned sulfimide chiral center on-tether of a thio-ether tethered peptide determines the peptide secondary structure by chemoselective oxaziridine modification. This method provides a facile way to tune peptides’ secondary structures and biophysical properties
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