An in-tether sulfilimine chiral center induces helicity in short peptides

A precisely positioned sulfilimine chiral center in the tether of a stabilized peptide would determine the peptide's secondary structure. Peptide sulfilimines could be prepared by a facile chloramine T oxidation and the two resulting peptide diastereomers showed significant differences in their secondary structures, which were supported by circular dichroism spectroscopy and NMR.National Natural Science Foundation of China [21102007, 31300600, 21372023]; MOST [2015DFA31590, 2013CB911500]; Shenzhen Science and Technology Innovation Committee [KQCX20130627103353535, SGLH20120928095602764, ZDSY20130331145112855, JSGG20140519105550503]; Shenzhen Peacock Program [KQTD201103]SCI(E)PubMedARTICLElizg@pkusz.edu.cn6810389-103915