An in-tether sulfilimine chiral center induces beta-turn conformation in short peptides

A sulfilimine chiral center in the tether at i, i + 3 positions of short peptides was systematically studied to elucidate the chiralitydriven conformational changes. A rare and unexpected type III beta-turn structure was induced in short peptides by an in-tether chiral center, supported by circular dichroism spectroscopy, NMR and X-ray crystallography.National Natural Science Foundation of China [21102007, 21374064, 31300600]; MOST [2013CB911500]; Shenzhen Science and Technology Innovation Committee [KQCX20130627103353535, SGLH20120928095602764]; Shenzhen Peacock Program [KQTD201103]SCI(E)PubMedARTICLEhecx@szu.edu.cn; wangtao@sustc.edu.cn; lizg@pkusz.edu.cn429993-99991