Alterations in hepatic oxylipins caused by chronic-binge ethanol exposure.

A, B: Heat maps representing the overall changes in hepatic metabolites derived from ω-6 and ω-3 PUFAs occurred between experimental groups. Results are expressed as a matrix view where rows represent individual metabolites and columns represent group distribution. The intensity of each color denotes the standardized ratio between each value and the average levels of each metabolite across all samples in all groups. C: The diagram summarizing differential levels of all PUFA-derived metabolites between the indicated treatment groups. n = 6 mice per group. AA, arachidonic acid; ALA, α-linolenic acid; DHA, docosahexaenoic acid; DGLA, dihomo-γ-linolenic acid; E, ethanol; EDA, eicosadienoic acid; EPA, eicosapentaenoic acid; SF, saturated fat; USF, unsaturated fat; Individual oxylipin abbreviations see in S2 and S4 Tables.