Immune response in thoracic LNs of cynomolgus macaques with granulomas.
- Sharie Keanne C. Ganchua (5921435)
- Anthony M. Cadena (2867072)
- Pauline Maiello (685403)
- Hannah P. Gideon (145934)
- Amy J. Myers (213750)
- Beth F. Junecko (5921438)
- Edwin C. Klein (3144645)
- Philana Ling Lin (81054)
- Joshua T. Mattila (251992)
- JoAnne L. Flynn (213763)
Publication date
November 2018
DOI Publisher
Public Library of Science (PLoS)Abstract
Cytokine production in thoracic LN with granuloma in response to ESAT6+CFP10 (A-B) or PDBu and ionomycin (C-E) between LNs with bacterial burden (CFU+, red) and those that cleared (CFU-, blue). A. Frequency of CD11b+ cells producing IL-10 (n = 10 macaques; 27 LNs); B. Frequency of CD4+ T cells producing TNF (n = 24 macaques; 48 LNs). C. Frequency of CD3+ cells producing IFNγ(n = 12 macaques; 35 LNs); D. Frequency of CD8+ cells producing IFNγ(n = 12 macaques, 34 LNs) IL-2 (n = 10 macaques; 28 LNs) and TNF (n = 12 macaques; 34 LNs); E. Frequency of CD20+ cells producing IL-2 (n = 11 macaques; 20 LNs). Each symbol represents a LN. Statistical test is Mann-Whitney.</p
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