Macaque T cell cytokine responses to empty MV.

<p>Total cytokine (sum of TNFα+, IL-2+ and IFNγ+ cells) response to MV by CD4+ and CD8+ T cells from peripheral blood (PBMCs), peripheral lymph nodes (PLN), mesenteric lymph nodes (MLN) and spleen (SPL). Time in days is shown on x-axis, all responses from PBMC unless prefixed by a tissue. Group A, macaques F51–F54, were immunised with 10⁵ TCID₅₀ MV1-F4 on days 0 and 28 whilst group B, macaques F55–F58, were immunised on day 0 only. Panels A and B shows cytokine responses gated on CD4+ T cells. Panels C and D show cytokine responses gated on CD8+ T cell. Dashed line represents the mean plus 3 standard deviations of day 0 responses, above which points were deemed significant.