Repertoire of macaque cytokine responses to HIV-1 F4 peptides.

<p>Single, double and triple cytokine (TNFα+, IL-2+ and IFNγ+ cells) responses by CD4+ (A and B) and CD8+ T cells (C and D) from peripheral blood (PBMCs), peripheral lymph nodes (PLN), mesenteric lymph nodes (MLN) and spleen (SPL). Group A, macaques F51–F54, were immunised with 10⁵ TCID₅₀ MV1-F4 on days 0 and 28 whilst group B, macaques F55–F58, were immunised on day 0 only. Columns represent group mean values ± SEM, n = 4. Single cytokine positive cells represented by IFNγ+ (blue), IL-2+ (green), TNFα+ (red), dual cytokine positive cells represented by IFNγ+ TNFα+ (purple), IL-2+ IFNγ+ (cyan), IL-2+ TNFα+ (orange), and triple cytokine positive cells represented by IL-2+IFNγ+TNFα+ (yellow) are plotted separately.