Model output was validated by simulating changes in NAD+ as a function of ATP perturbations. The model was run to steady state before perturbing ATP concentrations. Experimental data was taken from Devin et. al [37].</p
Model validation, parameter estimation and design of experiments are central, yet challenging proble...
The upper panel shows an updated model diagram of the Bazil et al. model [38] that includes calcium ...
Model validation, parameter estimation and design of experiments are central, yet challenging proble...
<p>We repeated each simulation 11 times to generate a sample of simulation variability, with some si...
<p><i>Panel A</i>. Rat lung mitochondria were incubated with fixed pyruvate (PYR) concentration (5 m...
(A): Comparison between our model-predicted, spatially averaged PCr/ATP ratio vs VO2 with model pred...
<p>(A) ATP-dependent concentration-response curves in the absence (black) and presence (red) of 3 μM...
<p>The steady-state level of phosphorylated CheY2 was measured in the presence or absence of the sin...
Predicted changes of the cytoplasmic NADPH/NADPratio of the unfitted model. The NADPH/NADPratio incr...
<p>Experiments were performed under the same experimental condition as in <a href="http://www.ploson...
<p>Obtained model solutions are shown by solid lines with filled symbols for models 1–4 and dashed l...
Cellular metabolism is one of the most fundamental systems for any living organisms, involving thous...
<p>(A) Superimposed catalytic potential plots for all personalized models. (B) Catalytic potential p...
In this work the correlation between levels of adenosine nucleotides and glycolytic flux was studied...
The top panels show the estimated treatment-versus-control contrasts comparing spiked and non-spiked...
Model validation, parameter estimation and design of experiments are central, yet challenging proble...
The upper panel shows an updated model diagram of the Bazil et al. model [38] that includes calcium ...
Model validation, parameter estimation and design of experiments are central, yet challenging proble...
<p>We repeated each simulation 11 times to generate a sample of simulation variability, with some si...
<p><i>Panel A</i>. Rat lung mitochondria were incubated with fixed pyruvate (PYR) concentration (5 m...
(A): Comparison between our model-predicted, spatially averaged PCr/ATP ratio vs VO2 with model pred...
<p>(A) ATP-dependent concentration-response curves in the absence (black) and presence (red) of 3 μM...
<p>The steady-state level of phosphorylated CheY2 was measured in the presence or absence of the sin...
Predicted changes of the cytoplasmic NADPH/NADPratio of the unfitted model. The NADPH/NADPratio incr...
<p>Experiments were performed under the same experimental condition as in <a href="http://www.ploson...
<p>Obtained model solutions are shown by solid lines with filled symbols for models 1–4 and dashed l...
Cellular metabolism is one of the most fundamental systems for any living organisms, involving thous...
<p>(A) Superimposed catalytic potential plots for all personalized models. (B) Catalytic potential p...
In this work the correlation between levels of adenosine nucleotides and glycolytic flux was studied...
The top panels show the estimated treatment-versus-control contrasts comparing spiked and non-spiked...
Model validation, parameter estimation and design of experiments are central, yet challenging proble...
The upper panel shows an updated model diagram of the Bazil et al. model [38] that includes calcium ...
Model validation, parameter estimation and design of experiments are central, yet challenging proble...
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