BALB/c mice were infected in the right ear with 4 × 106 antimony-resistant L. amazonensis promastigotes. Panel A: Lesion development on the animals treated orally with 2HF (50 mg/kg/day). Panel B: Lesion development on the animals treated intraperitoneally with meglumine antimoniate (100 mg/kg/day). The untreated mice (control group) were treated with an oral suspension added to DMSO (0.2% v/v) (2HF vehicle). The treatment started seven days post-infection and was given once daily seven times per week until the end of the experiment (day 42). Panel C: Parasite burden of the L. amazonensis-infected BALB/c mice untreated or treated with 2HF (50 mg/kg/day) or meglumine antimoniate (100 mg/kg/day). Ear parasite loads were determined via a limit...
The leishmanicidal activity of four batches of meglumine antimoniate, produced in Farmanguinhos-Fioc...
The leishmanicidal activity of four batches of meglumine antimoniate, produced in Farmanguinhos-Fioc...
<p>Mice (n = 8) were infected subcutaneously with 1×10<sup>6</sup> stationary promastigotes of <i>Le...
BALB/c mice were infected in the right ear with 2 × 106 wild-type L. amazonensis promastigotes. Pane...
<p>The right ears of the mice were infected intradermally with 2×10<sup>6 </sup><i>L. braziliensis</...
Macrophages were infected with wild-type or antimony-resistant L. amazonensis promastigotes at 37°C ...
Comparative IC50 of meglumine antimoniate and 2HF against L. amazonensis-infected macrophages using ...
<p>Lesion size represents the average difference between infected and contralateral non-infected hin...
The leishmanicidal activity of four batches of meglumine antimoniate, produced in Farmanguinhos-Fioc...
a<p>equivalent to 5.4 mg Sb<sup>V</sup>/kg/day.</p>b<p>Saline <i>vs</i> Tamoxifen: <i>P</i><0.05 and...
<p>C57BL/6 or BALB/c mice were infected with 10<sup>6</sup><i>L</i>. <i>amazonensis</i> promastigote...
<p>Female BALB/c mice (n = 33) were infected with 5 × 10<sup>6</sup><i>L</i>. <i>major</i> promastig...
The leishmanicidal activity of four batches of meglumine antimoniate, produced in Farmanguinhos-Fioc...
Leishmaniasis, a disease caused by parasites of the Leishmania genus, constitutes a significant heal...
Background: Leishmaniasis is a common parasitic disease in Southern Europe, caused by Leishmania inf...
The leishmanicidal activity of four batches of meglumine antimoniate, produced in Farmanguinhos-Fioc...
The leishmanicidal activity of four batches of meglumine antimoniate, produced in Farmanguinhos-Fioc...
<p>Mice (n = 8) were infected subcutaneously with 1×10<sup>6</sup> stationary promastigotes of <i>Le...
BALB/c mice were infected in the right ear with 2 × 106 wild-type L. amazonensis promastigotes. Pane...
<p>The right ears of the mice were infected intradermally with 2×10<sup>6 </sup><i>L. braziliensis</...
Macrophages were infected with wild-type or antimony-resistant L. amazonensis promastigotes at 37°C ...
Comparative IC50 of meglumine antimoniate and 2HF against L. amazonensis-infected macrophages using ...
<p>Lesion size represents the average difference between infected and contralateral non-infected hin...
The leishmanicidal activity of four batches of meglumine antimoniate, produced in Farmanguinhos-Fioc...
a<p>equivalent to 5.4 mg Sb<sup>V</sup>/kg/day.</p>b<p>Saline <i>vs</i> Tamoxifen: <i>P</i><0.05 and...
<p>C57BL/6 or BALB/c mice were infected with 10<sup>6</sup><i>L</i>. <i>amazonensis</i> promastigote...
<p>Female BALB/c mice (n = 33) were infected with 5 × 10<sup>6</sup><i>L</i>. <i>major</i> promastig...
The leishmanicidal activity of four batches of meglumine antimoniate, produced in Farmanguinhos-Fioc...
Leishmaniasis, a disease caused by parasites of the Leishmania genus, constitutes a significant heal...
Background: Leishmaniasis is a common parasitic disease in Southern Europe, caused by Leishmania inf...
The leishmanicidal activity of four batches of meglumine antimoniate, produced in Farmanguinhos-Fioc...
The leishmanicidal activity of four batches of meglumine antimoniate, produced in Farmanguinhos-Fioc...
<p>Mice (n = 8) were infected subcutaneously with 1×10<sup>6</sup> stationary promastigotes of <i>Le...