In vivo antileishmanial efficacy of miltefosine against Leishmania (Leishmania) amazonensis
- Garcia Bustos, Maria Fernanda
- Barrio, Alejandra
- Prieto, Gabriela G.
- De Raspi, Emma M.
- Cimino, Rubén Oscar
- Cardozo, Rubén Marino
- Parada, Luis Antonio
- Yeo, Matthew
- Soto, Jaime
- Uncos, Delfor Alejandro
- Parodi Ramoneda, Cecilia María
- Basombrío, Miguel Ángel Manuel
DOIAbstract
Leishmaniasis, a disease caused by parasites of the Leishmania genus, constitutes a significant health and social problem in many countries and is increasing worldwide. The conventional treatment, meglumine antimoniate (MA), presents numerous disadvantages, including invasiveness, toxicity, and frequent therapeutic failure, justifying the attempts at finding alternatives to the first-line therapy. We have studied the comparative long-term efficacy of MA against miltefosine (MF) in Leishmania infection in experimental mice. The criteria for efficacy evaluation were footpad lesion size, anti-Leishmania antibodies level, histopathology of the site of inoculation (right footpad, RFP), splenic index (SI), and the presence of parasites in RFP, sp...
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