Additional file 4 of Mind the gaps: overlooking inaccessible regions confounds statistical testing in genome analysis

Distribution of the observed test statistic and the average test statistic under the null model for DNase I hypersensitive sites (hg38). Distribution of the test statistic and p-values of colocalization analysis for a collection of 95 genomic tracks with 150.35 bp average segment length. (a) and (b) shows the distribution of p-values of the colocalization analysis with (left) and without (right) exclusion of assembly gap regions under the null model. (c) and (d) shows the observed test statistic and the average test statistic of the same tracks with (left) and without (right) exclusion of assembly gap regions under the null model. (PDF 72 kb