Additional file 2: of XGR software for enhanced interpretation of genomic summary data, illustrated by application to immunological traits

Exploring the statistical test for enrichment through null simulations. The hypergeometric test is used for DO enrichment analysis applied to a set of genes, namely differentially expressed genes induced by IFN-Îł treatment of primary human monocytes [24], identifying eight enriched terms (FDR <0.05). To estimate the chance of these enriched terms resulting from the real data that would be expected from a null distribution, we simulate a random set of genes (having the same number of genes as in the real data) for 10,000 times. Applying DO enrichment analysis to the simulated data, we count how often each enriched term is called significant under FDR