CSD inhibits AngII-induced increases in integrin levels and NTK activation in the heart and kidney.

Mice were infused with AngII or saline for 2 wk and received daily i.p. injections of CSD or vehicle. (A) RIPA extracts of LV tissue were used in Western blotting experiments with antibodies against β1 and β3 integrins, phospho-Pyk2-Y402, and GAPDH (loading control). Graphs show quantitation of Western blots using 4 independent mice for each group. Statistically significant changes are shown as **p B) RIPA extracts of kidney tissue were used in Western blotting experiments with antibodies against β1 and β3 integrins, phospho-Pyk2-Y402, and GAPDH (loading control). Graphs show quantitation of Western blots using 4 independent mice for each group. Statistically significant changes are shown as **p < 0.01, ***p < 0.001 for Sham+Veh vs AngII+Veh and ^p < 0.05, ^^p < 0.01, ^^^p < 0.001 for AngII+Veh vs AngII+CSD.