MCS stimulates angiogenesis.

(A) Cryo-sections of ND, D, and D + MCS wounds were stained for Ang-1 (Cy3), PECAM (FITC), Tie1 (FITC), and VE-cadherin (Cy3) and counterstained with DAPI to demarcate the nuclei. Scale bars for images = 20 μm; the data are representative of 4 mice in each group. White arrows indicate the areas of positive signals for Ang-1, PECAM, Tie1, and VE-cadherin expression. (B)Distinct VE-cadherin-positive cell junctions within the wound sections. White arrows indicate cell-cell junctions.(C) Mean fluorescence intensity data of images shown in (A) obtained from four independent experiments. ***P<0.001.