Disease models without main effects, taken from [31], where they were specifically constructed in such a way that there is no individual association between either SNP and the disease.</p
a<p>In each schema, three two-locus interaction models (additive × additive, dominant × dominant and...
Schematic representation of an epidemic model (Source: Adapted from Kostova et al., [122]).</p
<p>(I) A recessive causative variant (black star) is associated with only the <b><i>ab</i></b> SNP h...
Disease models for the two pairs of SNPs that contribute to the simulated outcome. Numeric values (e...
<p><i>δ</i> represents the impact value of the genotype at SNP location when there is no epistasis b...
Nodes are labeled with the reference of the associated studies (year abbreviated), shaped by model c...
<p>In scenario I, only phenotype 1 is associated with the SNP. <i>rG</i> = 1 or −1 does not affect t...
<p>The first to third columns denote the effect sizes of SNP1, SNP2 and interaction in pure samples ...
<p>We compare results of model simulation with data from [<a href="http://www.plosone.org/article/in...
A list of non-simulated SNP sets (ascertainment schemes) analyzed in this study and their sizes.</p
From the assessment of statistical interaction between risk factors it is tempting to infer the natu...
<p>(A) 20% associated SNPs for each phenotype and 75% extra overlaps between and and between and ...
<p>Each entry in the tables represents the risk of the corresponding genotype combination relative t...
A “1” means the corresponding genotype combination, e.g., “aabb” in (c), would elevate the risk of d...
<p>(A) QQ plot of -log10 p values from SNP set tests using different SNP weights under the null simu...
a<p>In each schema, three two-locus interaction models (additive × additive, dominant × dominant and...
Schematic representation of an epidemic model (Source: Adapted from Kostova et al., [122]).</p
<p>(I) A recessive causative variant (black star) is associated with only the <b><i>ab</i></b> SNP h...
Disease models for the two pairs of SNPs that contribute to the simulated outcome. Numeric values (e...
<p><i>δ</i> represents the impact value of the genotype at SNP location when there is no epistasis b...
Nodes are labeled with the reference of the associated studies (year abbreviated), shaped by model c...
<p>In scenario I, only phenotype 1 is associated with the SNP. <i>rG</i> = 1 or −1 does not affect t...
<p>The first to third columns denote the effect sizes of SNP1, SNP2 and interaction in pure samples ...
<p>We compare results of model simulation with data from [<a href="http://www.plosone.org/article/in...
A list of non-simulated SNP sets (ascertainment schemes) analyzed in this study and their sizes.</p
From the assessment of statistical interaction between risk factors it is tempting to infer the natu...
<p>(A) 20% associated SNPs for each phenotype and 75% extra overlaps between and and between and ...
<p>Each entry in the tables represents the risk of the corresponding genotype combination relative t...
A “1” means the corresponding genotype combination, e.g., “aabb” in (c), would elevate the risk of d...
<p>(A) QQ plot of -log10 p values from SNP set tests using different SNP weights under the null simu...
a<p>In each schema, three two-locus interaction models (additive × additive, dominant × dominant and...
Schematic representation of an epidemic model (Source: Adapted from Kostova et al., [122]).</p
<p>(I) A recessive causative variant (black star) is associated with only the <b><i>ab</i></b> SNP h...
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