P14 mutant cortices do not display increased densities of PDGFRα<sup>+</sup> or OLIG2<sup>+</sup> cells.
- Michael C. Holter (6630959)
- Lauren. T. Hewitt (6630962)
- Stephanie V. Koebele (6630965)
- Jessica M. Judd (6630968)
- Lei Xing (129950)
- Heather A. Bimonte-Nelson (5341175)
- Cheryl D. Conrad (6630971)
- Toshiyuki Araki (488507)
- Benjamin G. Neel (162598)
- William D. Snider (206705)
- Jason M. Newbern (6630974)
Publication date
April 2019
DOI Publisher
Public Library of Science (PLoS)Abstract
A-H: Sensory cortices from P14 control (A-B, E-F) and Raf1L613V/wt (C-D, G-H) mice, immunolabeled for PDGFRα (A-D) or OLIG2 (E-H), show no relative difference in OPC cell density (O) (mean ± SEM, n = 3). I-L: Immunolabeling for an alternate marker of OPCs, NG2, in P30 control (I-J) and mutant (K-L) brains also results in no changes in relative density of labeled cells (P) (mean ± SEM, n = 3). M-N: PDGFRα immunolabeling (arrows) revealed a significant increase in the number of OPCs in mutant cortices in comparison to controls (P) (mean ± SEM, n = 3). All scale bars = 50μm.</p
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