DCD is strikingly decreased in HS lesions.
- Margaret Coates (6058580)
- Paula Mariottoni (6668048)
- David L. Corcoran (10017)
- Hélène Fradin Kirshner (6668051)
- Tarannum Jaleel (6668054)
- David A. Brown (310162)
- Stephen R. Brooks (738341)
- John Murray (434182)
- Maria I. Morasso (255438)
- Amanda S. MacLeod (6058586)
Publication date
May 2019
DOI Publisher
Public Library of Science (PLoS)Abstract
(A) qPCR for DCD (log2FC = -3.57, *p < 0.05). FC is expressed as average of skin samples from 3 patients. Measurements were collected in triplicate or duplicate, as allowed by RNA yield from samples. Data is shown as mean FC over non-lesional skin +/- the standard error of the mean. Non-lesional and lesional samples were compared using a paired t-test. (B) Immunofluorescence for DCD (red) at 40X in normal skin, HS non-lesional skin, and HS lesional skin. Co-staining was performed with K77 (green), which is a marker of eccrine sweat glands. Scale bar is 100μm. (C) Immunofluorescence for DCD (red) and K77 (green) at 4X showing decreased number of eccrine sweat glands in HS lesional skin. Scale bar is 500μm.</p
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