PERP loss with E-cadherin maintenance is a common event in human skin SCCs.

<p>A) Representative PERP and E-cadherin immunostaining of SCCs illustrating different expression patterns at low (left 100∶1) and high (right 400∶1) power magnification. Examples of PERP+;E- cadherin+ (i), PERP−;E-cadherin− (ii), and PERP−;E- cadherin+ (iii) tumors are shown. Dashed boxes indicate regions shown in the high magnification images. B) Table quantifying the numbers and percentages of SCCs with specific staining patterns for PERP and E- cadherin expression. Note the high percentage of tumors exhibiting strong E-cadherin staining, but no PERP staining.