A-D) Phospho-SMAD2 stained sections from animals 7 days after anti-GBM antibody treatment. A, B) control antibody stained sections show weak tubular nuclear staining (arrow, A). Anti-GBM antibody treated mice demonstrate pSMAD2 staining in proliferative crescentic areas (open arrow, C, D). Occasional glomerular cells positive (arrow C), and some tubular epithelial cell positivity (short arrows). Scale bars are 200 um. </p
<p>RAW cells were exposed to 10 ng/ml TGFβ1 for 45 minutes. A) phospho-SMAD2 and B) phospho-SMAD3 we...
<p>c/gcs, cells per glomerular cross section; c/hpf, cells per high power field.</p><p>*P = 0.02.</p...
(A) Direct immunofluorescence detection of IgG autoantibodies bound to GBM. (B) Immunofluorescence s...
<p>Following the challenge with anti-GBM serum, 129×1/SvJ mice (<i>n</i> = 3–9 per group) showed inc...
<p>(A) Proteinuria (dotted line represents measured level in non-nephritic WT mice, n = 4). (B) Seru...
<p>Periodic acid-Schiff reagent (PAS) stain of a control kidney (A) and kidneys affected by crescent...
<p>(A) Experimental design. (B) Proteinuria. (C) Percentage of glomerular crescents and (D) glomerul...
<p><i>129/svj</i> mice were challenged with anti-GBM antibody on day 0 and then treated with hKLK1-M...
<p>Kidneys from mice 4 weeks after induction of anti-GBM-GN with or without EGCG treatment and kidne...
<p>(A) Experimental design. (B) Survival following the induction of nephritis. Black bars represent ...
<p>Kidneys from mice 4 weeks after induction of anti-GBM-GN with or without EGCG treatment and kidne...
<p>(<i>a</i>) Increased Scr after anti-GBM serum challenge. On D12, each nephritis group showed sign...
<p>Histological staining with PAS and hematoxylin shows the structure of kidney tubules in (A) a nor...
<p>(A) Kidneys double-stained for PC and PNA, from untreated ht (upper panels) and mt (middle panels...
<p>Histological staining with PAS and hematoxylin shows the kidney structure of (A) a normal mouse. ...
<p>RAW cells were exposed to 10 ng/ml TGFβ1 for 45 minutes. A) phospho-SMAD2 and B) phospho-SMAD3 we...
<p>c/gcs, cells per glomerular cross section; c/hpf, cells per high power field.</p><p>*P = 0.02.</p...
(A) Direct immunofluorescence detection of IgG autoantibodies bound to GBM. (B) Immunofluorescence s...
<p>Following the challenge with anti-GBM serum, 129×1/SvJ mice (<i>n</i> = 3–9 per group) showed inc...
<p>(A) Proteinuria (dotted line represents measured level in non-nephritic WT mice, n = 4). (B) Seru...
<p>Periodic acid-Schiff reagent (PAS) stain of a control kidney (A) and kidneys affected by crescent...
<p>(A) Experimental design. (B) Proteinuria. (C) Percentage of glomerular crescents and (D) glomerul...
<p><i>129/svj</i> mice were challenged with anti-GBM antibody on day 0 and then treated with hKLK1-M...
<p>Kidneys from mice 4 weeks after induction of anti-GBM-GN with or without EGCG treatment and kidne...
<p>(A) Experimental design. (B) Survival following the induction of nephritis. Black bars represent ...
<p>Kidneys from mice 4 weeks after induction of anti-GBM-GN with or without EGCG treatment and kidne...
<p>(<i>a</i>) Increased Scr after anti-GBM serum challenge. On D12, each nephritis group showed sign...
<p>Histological staining with PAS and hematoxylin shows the structure of kidney tubules in (A) a nor...
<p>(A) Kidneys double-stained for PC and PNA, from untreated ht (upper panels) and mt (middle panels...
<p>Histological staining with PAS and hematoxylin shows the kidney structure of (A) a normal mouse. ...
<p>RAW cells were exposed to 10 ng/ml TGFβ1 for 45 minutes. A) phospho-SMAD2 and B) phospho-SMAD3 we...
<p>c/gcs, cells per glomerular cross section; c/hpf, cells per high power field.</p><p>*P = 0.02.</p...
(A) Direct immunofluorescence detection of IgG autoantibodies bound to GBM. (B) Immunofluorescence s...
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