Renal dysfunction and pathological damage following anti-GBM nephritis.

<p>(<i>a</i>) Increased Scr after anti-GBM serum challenge. On D12, each nephritis group showed significantly higher levels of Scr than that on D0 (N = 4–5 for each group, <i>P</i><0.003), whereas, there was no significant difference in Src levels among the three groups (<i>b–c</i>). Severe pathological damage was seen in the nephritis group on D12, as evidenced by crescent formation in the nephritis group and by an increased GN score (N = 3 for each group, <i>P</i><0.0001). (<i>d–e</i>) Representative pathological changes in diseased mice in glomeruli (d) and tubulointerstitium are shown (e). The solid arrow indicates crescent formation; the asterisk indicates dilated distal tubules filled with protein cast; the dotted arrow shows infiltrating cells.