KDR channel.

<p>(A) Voltage dependence of steady state activation (<i>n</i>_∞) of the modelled channel [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006293#pcbi.1006293.ref021" target="_blank">21</a>]. (B) The activation time constant (<i>τ</i>_<i>n</i>) of the channel: solid line = simulation (Sim.) and squares = experimental data for bladder small DRG neurons (Expt.) from [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006293#pcbi.1006293.ref033" target="_blank">33</a>]. (C) The currents (<i>I</i>_<i>KDR</i>) generated by the model (solid lines) and the corresponding currents reported in experiments (symbols, [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006293#pcbi.1006293.ref007" target="_blank">7</a>]) for bladder small DRG neurons using rectangular voltage clamp protocol. The holding potential was kept at −40 mV and test potentials of −20, −10 and 0 mV were applied for 300 ms. Experimental clamp currents: triangles (0 mV), squares = −10 mV and circles = −20 mV. (D) Steady state I-V relationship generated from model (solid line) and recorded from experiments (squares) for bladder small DRG neurons [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006293#pcbi.1006293.ref033" target="_blank">33</a>] by plotting the steady state current at end of each test potential. Protocol: Rectangular voltage clamp steps were applied from −80 to 10 mV in steps of 10 mV. The holding potential was −40 mV. Other model parameters: , <i>E</i>_<i>K</i> = −84.7 mV, RMP = −53.5 mV, soma capacitance = 28 pF, soma diameter = 24 <i>μ</i>m. The S values for model fits and their 5% threshold values (given in brackets) are: for voltage clamp currents at: 0 mV = 0.045 nA (0.029 nA), −10 mV = 0.029 nA (0.016 nA) & −20 mV = 0.031 nA (0.006 nA), and I-V curve = 0.043 nA (0.066 nA).