Comparison of normalized experimental and simulated [Ca]_i and [Ca]_MT.

<p>The solid red line and solid blue line represent the simulated [Ca]_i and [Ca]_MT, respectively from the model (Sim.), obtained by evoking 20 APs at 10 Hz. APs were evoked by using rectangular current clamps of 1.25 nA and 1 ms. The red circles and blue triangles are experimental traces digitized (Expt.) [Ca]_i and [Ca]_MT for similar stimuli in small DRG neuron terminals obtained from [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006293#pcbi.1006293.ref106" target="_blank">106</a>]. The rising and falling dynamics of our bladder small DRG soma model output closely compares with those recorded experimentally. The S value for [Ca]_i and [Ca]_MT fits and their 5% thresholds (in brackets) are 0.12 (0.05) and 0.068 (0.05), respectively. Effects of calcium dye buffering were included in the simulations.